Anti-PAX5 Antibody [JJ08-87]

About this product

The Pax family of nuclear transcription factors is comprised of nine members that function during embryogenesis to regulate the temporal and position-dependent differentiation of cells. Pax family genes are also involved in a variety of signal transduction pathways in the adult organism. Mutations in Pax proteins have been linked to disease and cancer in humans. For example, the human PAX5 gene encodes a B cell lineage-specific protein, Pax-5, also designated B cell specific activator protein or BSAP, which is expressed in pro-B, pre-B and mature B lymphocytes but not in plasma cells. Pax-5 functions to regulate not only B cell development, but also influences the balance between immunoglobulin secretion and B cell proliferation. Overexpression of Pax-5 has been implicated in cellular transformation, and in the case of small lymphocytic lymphomas with plasmacytoid differentiation, a t (9;14) (p13;q32) translocation resulting in the deregulation of PAX5 gene expression has been detected.

Specifications

Catalog number

ET1701-49TR

Size / count

20 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

B cell lineage specific activator antibody B cell lineage specific activator protein antibody B cell specific activator protein antibody B cell specific transcription factor antibody B-cell-specific transcription factor antibody BSAP antibody EBB-1 antibody KLP antibody Paired box 5 antibody Paired box gene 5 (B cell lineage specific activator protein) antibody Paired box gene 5 (B cell lineage specific activator) antibody Paired box gene 5 antibody Paired box homeotic gene 5 antibody Paired box protein Pax 5 antibody Paired box protein Pax-5 antibody Paired domain gene 5 antibody PAX 5 antibody PAX5 antibody PAX5_HUMAN antibody Transcription factor PAX 5 antibody

Abbreviation

BSAP

Swiss Prot

Q02548 Human; Q02650 Mouse

Cellular Locus

Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Synthetic peptide within human PAX5 aa 240-280.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, FC

Positive Control

Ramos cell lysate, Raji cell lysate, Daudi cell lysates, Hela, MCF-7, HepG2, human lymph nodes tissue, human tonsil tissue, human spleen tissue, Raji.

Concentration

1 mg/mL

Dilution

WB: 1:5,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:400-1:1,000 ;FC: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 42 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

True