Anti-Hemoglobin subunit gamma 1and2 Antibody [JM84-10]

About this product

Hemoglobin (Hgb) is coupled to four iron-binding, methene-linked tetrapyrrole rings (heme). The α (16p13.3; 5′-ζ-pseudoz-pseudo α2-pseudo α1-α2-α1-?1-3′) and β (11p15.5) globin loci determine the basic hemoglobin structure. The globin portion of hemoglobin consists of two α chains and two β chains arranged in pairs forming a tetramer. Each of the four globin chains covalently associates with a heme group. The bonds between α and β chains are weaker than between similar globin chains, thereby forming a cleavage plane that is important for oxygen binding and release. High affinity for oxygen occurs upon relaxation of the α1-β2 cleavage plane. When the two α1-β2 interfaces are closely bound, hemoglobin has a low affinity for oxygen. Hb A, which contains two α chains plus two β chains, comprises 97% of total circulating hemoglobin. The remaining 3% of total circulating hemoglobin is comprised of Hb A-2, which consists of two α chains plus two δ chains, and fetal hemoglobin (Hb F), which consists of two α chains together with two γ chains.

Specifications

Catalog number

ET1703-46TR

Size / count

20 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

Hemoglobin subunit gamma-1 Gamma-1-globin Hb F Agamma Hemoglobin gamma-1 chain Hemoglobin gamma-A chain HBG1 PRO2979 Abnormal hemoglobin antibody FLJ76540 antibody G gamma globin antibody Gamma 2 globin antibody Gamma-2-globin antibody Hb F Ggamma antibody HBG 2 antibody HBG2 antibody HBG2_HUMAN antibody Hemoglobin gamma 2 chain antibody Hemoglobin gamma G antibody Hemoglobin gamma G chain antibody Hemoglobin gamma-2 chain antibody Hemoglobin gamma-G chain antibody Hemoglobin subunit gamma 2 antibody Hemoglobin subunit gamma-2 antibody Methemoglobin antibody OTTHUMP00000069638 antibody

Abbreviation

HBG1, HBG2

Swiss Prot

P69891 Human; P69892 Human

Cellular Locus

Cytosol, hemoglobin complex.

Host

Rabbit

Species Reactivity

Human, Rat

Immunogen

Synthetic peptide within Human HBG1 / 2 aa 2-45 / 147.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P

Positive Control

Human placenta tissue lysate, human brain tissue lysate, human placenta tissue, human stomach tissue (negative).

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:5,000 ;IF-Cell: 1:50-1:100 ;IF-Tissue: 1:50-1:100 ;IHC-P: 1:1000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 16 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

True