Anti-Alpha Synuclein Antibody [JB42-33]

About this product

Alpha-synuclein is a protein that, in humans, is encoded by the SNCA gene. Alpha-synuclein is a neuronal protein that regulates synaptic vesicle trafficking and subsequent neurotransmitter release. It is abundant in the brain, while smaller amounts are found in the heart, muscle and other tissues. In the brain, alpha-synuclein is found mainly in the axon terminals of presynaptic neurons. Within these terminals, alpha-synuclein interacts with phospholipids and proteins. Presynaptic terminals release chemical messengers, called neurotransmitters, from compartments known as synaptic vesicles. The release of neurotransmitters relays signals between neurons and is critical for normal brain function. The human alpha-synuclein protein is made of 140 amino acids. An alpha-synuclein fragment, known as the non-Abeta component (NAC) of Alzheimer's disease amyloid, originally found in an amyloid-enriched fraction, was shown to be a fragment of its precursor protein, NACP. It was later determined that NACP was the human homologue of Torpedo synuclein. Therefore, NACP is now referred to as human alpha-synuclein.

Specifications

Catalog number

ET7107-31TR

Size / count

20 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

Alpha synuclein antibody Alpha-synuclein antibody Alpha-synuclein, isoform NACP140 antibody alphaSYN antibody MGC105443 antibody MGC110988 antibody MGC127560 antibody MGC64356 antibody NACP antibody Non A beta component of AD amyloid antibody Non A4 component of amyloid antibody Non A4 component of amyloid precursor antibody Non-A beta component of AD amyloid antibody Non-A-beta component of alzheimers disease amyloid , precursor of antibody Non-A4 component of amyloid precursor antibody Non-A4 component of amyloid, precursor of antibody OTTHUMP00000218549 antibody OTTHUMP00000218551 antibody OTTHUMP00000218552 antibody OTTHUMP00000218553 antibody OTTHUMP00000218554 antibody PARK 1 antibody PARK 4 antibody PARK1 antibody PARK4 antibody Parkinson disease (autosomal dominant, Lewy body) 4 antibody Parkinson disease familial 1 antibody SNCA antibody Snca synuclein, alpha (non A4 component of amyloid precursor) antibody SYN antibody Synuclein alpha antibody Synuclein alpha 140 antibody Synuclein, alpha (non A4 component of amyloid precursor) antibody SYUA_HUMAN antibody

Abbreviation

NACP, SNCA, NACP, PARK1

Swiss Prot

P37840 Human; O55042 Mouse

Cellular Locus

Secreted, nucleus, cytoplasm, membrane, synapse.

Host

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant full length protein of human Alpha Synuclein.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, IP, FC

Positive Control

Human brain tissue lysates, Hela, mouse brain tissue, SH-SY5Y.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200;FC: 1:50-1:100;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 14 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

True