Human CD27/TNFRSF7 Recombinant Rabbit Monoclonal Antibody [PSH08-31] - BSA and Azide free (Capture)

Catalog number HA722973

Price for HA722973

Size / count 100 µL

About this product

Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells. The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells. Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory. In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis. Negatively regulates the function of Th2 lymphocytes in the adipose tissue. An autosomal recessive immunodeficiency disorder associated with persistent symptomatic EBV viremia, hypogammaglobulinemia, and impaired T-cell-dependent B-cell responses and T-cell dysfunction. The phenotype is highly variable, ranging from asymptomatic borderline-low hypogammaglobulinemia, to a full-blown symptomatic systemic inflammatory response with life-threatening EBV-related complications, including hemophagocytic lymphohistiocytosis, a lymphoproliferative disorder, and malignant lymphoma requiring stem cell transplantation.

Specifications

Catalog number: HA722973
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: CD 27 antibody CD27 antibody CD27 antigen antibody CD27 molecule antibody CD27_HUMAN antibody CD27L receptor antibody LPFS2 antibody MGC20393 antibody OTTHUMP00000238557 antibody S152 antibody T cell activation antigen CD27 antibody T cell antivation antigen S152 antibody T-cell activation antigen CD27 antibody T14 antibody TNFRSF 7 antibody TNFRSF7 antibody TNFSF7 antibody Tp 55 antibody Tp55 antibody Tumor necrosis factor receptor superfamily member 7 antibody
Abbreviation: CD27 antigen CD27L receptor T-cell activation antigen CD27 T14 Tumor necrosis factor receptor superfamily member 7 CD27 TNFRSF7
Swiss Prot: P26842 Human
Cellular Locus: Cell membrane.
Host: Rabbit
Species Reactivity: Human
Immunogen: Recombinant protein within Human CD27 aa 20-191 (HA210880).
Isotype: IgG
Clone: PSH08-31
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: ELISA (Cap)
Positive Control: Recombinant Human CD27 protein (HA210880).
Concentration: 1mg/mL
Dilution: ELISA (Cap): Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PSH08-33] to Human CD27 antibody (Detector) (HA722975) and Recombinant Human CD27 protein (HA210880) as the standard. The reference range value is 12.3-4,000 pg/ml.
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4).
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for Human CD27/TNFRSF7 Recombinant Rabbit Monoclonal Antibody [PSH08-31] - BSA and Azide free (Capture)?

The catalog number for Human CD27/TNFRSF7 Recombinant Rabbit Monoclonal Antibody [PSH08-31] - BSA and Azide free (Capture) is HA722973.

What sizes are available for Human CD27/TNFRSF7 Recombinant Rabbit Monoclonal Antibody [PSH08-31] - BSA and Azide free (Capture)?

Human CD27/TNFRSF7 Recombinant Rabbit Monoclonal Antibody [PSH08-31] - BSA and Azide free (Capture) is available in the following size(s): 100 µL.

Is Human CD27/TNFRSF7 Recombinant Rabbit Monoclonal Antibody [PSH08-31] - BSA and Azide free (Capture) in stock?

Human CD27/TNFRSF7 Recombinant Rabbit Monoclonal Antibody [PSH08-31] - BSA and Azide free (Capture) is currently made to order / not held in immediate stock. Contact us for lead time.

What is Human CD27/TNFRSF7 Recombinant Rabbit Monoclonal Antibody [PSH08-31] - BSA and Azide free (Capture) used for?

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.

Can I get a trial-size or discounted first order of this product?

We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.