Fyn Rabbit Polyclonal Antibody

About this product

Fyn is a protein, present in the signaling pathway of integrins, which activates ras. Fyn is a tyrosine-specific phospho-transferase that is a member of the Src family of non-receptor tyrosine protein kinases. (This family also includes Abl, Src, focal adhesion kinase and Janus kinase.) Fyn is located downstream of several cell surface receptors, commonly associated with neuronal development and T-cell signaling. When fyn is activated it causes downstream activation of molecular signals that drive processes crucial to growth and motility of cells. Fyn is primarily localized to the cytoplasmic leaflet of the plasma membrane, where it phosphorylates tyrosine residues on key targets involved in a variety of different signaling pathways. Tyrosine phosphorylation of target proteins by Fyn serves to either regulate target protein activity, and/or to generate a binding site on the target protein that recruits other signaling molecules. Fyn also is a tumor suppressor. When this normal biology is compromised, the altered Fyn becomes involved in the neoplastic transformation of normal cells to cancerous ones following the pathway from pre-invasive, to invasive, and ultimately metastasis. Fyn also appears to play an important role in fertilization including in the rapid Inositol trisphosphate-mediated calcium signaling which occurs when oocyte and sperm interact. Fyn expression levels are much higher in oocytes than even neurons and T-cells and it has been suggested to be an ‘oocyte-specific kinase’. Several studies point to Fyn as being responsible for dramatic biochemical changes in the oocyte cortex during oocyte maturation. Fyn may also play an important role in proper shaping of sperm head and acrosome within the testis and possibly has an additional role in the sperm acrosome reaction.

Specifications

Catalog number

ER1706-74

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

C syn protooncogene antibody Fyn antibody FYN oncogene related to SRC FGR YES antibody FYN_HUMAN antibody OKT3 induced calcium influx regulator antibody P59 FYN antibody p59-Fyn antibody Protein tyrosine kinase fyn antibody Proto oncogene tyrosine protein kinase fyn antibody Proto-oncogene c-Fyn antibody Proto-oncogene Syn antibody Protooncogene Syn antibody SLK antibody Src like kinase antibody Src yes related novel gene antibody Src-like kinase antibody Src/yes related novel antibody SYN antibody Tyrosine kinase p59fyn T antibody Tyrosine kinase p59fyn (T) antibody Tyrosine-protein kinase Fyn antibody

Abbreviation

SLK, FYN

Swiss Prot

P06241 Human, P39688 Mouse, Q62844 Rat

Cellular Locus

Cytoplasm. Membrane. Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within N-terminal human Fyn.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC

Positive Control

HUVEC, N2A, SH-SY5Y, rat brain tissue, human tonsil tissue, human spleen tissue, mouse testis tissue, mouse brain tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500;IF-Cell: 1:100-1:500;IHC-P: 1:50-1:200;FC: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 61 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No