MUC5AC Recombinant Mouse Monoclonal Antibody [A10G5-R]

Catalog number HA601181

Price for HA601181

Size / count 100 µL

About this product

Mucins are a group of high molecular weight glycoproteins consisting of a mucin core protein and O-linked carbohydrates. Mucin 6 carries GlcNAca1-->4Galb-->R structures, indicating that alpha1, 4-N-acetylglucosaminyltransferase is important to the formation of the mucous glycoproteins in vivo. Mucin 5AC is a gel-forming mucin that is secreted from surface mucous cells. Glucocorticoid is required for the expression of Mucin 5AC mRNA and high doses of hydrocortisone suppress its expression. Additionally, asthmatic fluid stimulates Mucin 5AC synthesis several-fold. The pro-inflammatory cytokines IL-6 and TNF-alpha stimulate Mucin 5AC secretion and thus contribute to the upregulation of mucin by chronic inflammation. Expression of Mucin 5AC is retinoic acid (RA)- or retinol- dependent and RA control of mucin genes is mediated by the retinoid acid receptor RARα and, to a lesser extent, by RARγ. Thyroid hormone binding to thyroid receptors inhibits Mucin 5AC gene expression. Mucin 5AC is also expressed in normal endocervical epithelium, small intestine, gastric cells (Lewis type 1) and gastric metaplasia, and it is a one of the major mucins in the ethmoid mucosa.

Specifications

Catalog number: HA601181
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: Apomucin antibody Apomucin Major Airway Glycoprotein antibody Gastric mucin antibody LeB antibody Lewis B blood group antigen antibody Major Airway Glycoprotein antibody MUC 5 antibody MUC5 antibody MUC5AC antibody Mucin 5 subtype AC tracheobronchial antibody Mucin 5 Subtypes A And C antibody Mucin 5 subtypes A and C tracheobronchial/gastric antibody Mucin 5, tracheobronchial/gastric antibody Mucin 5AC antibody Mucin 5AC oligomeric mucus/gel forming antibody Mucin 5AC, oligomeric mucus/gel forming pseudogene antibody Mucin antibody TBM antibody Tracheobronchial Mucin (TBM) antibody Tracheobronchial mucin antibody
Abbreviation: Mucin-5AC MUC-5AC TBM MUC5AC MUC5
Swiss Prot: P98088 Human,
Cellular Locus: Secreted.
Host: Mouse
Species Reactivity: Human, Mouse
Immunogen: Recombinant protein within Human MUC5AC aa 600-850.
Isotype: IgG1
Clone: A10G5-R
Conjugation: Non-conjugated
Type: Recombinant Mouse monoclonal Antibody
Applications: IHC-P
Positive Control: Human stomach tissue, mouse stomach tissue.
Concentration: 1 mg/mL
Dilution: IHC-P: 1:1,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 586 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for MUC5AC Recombinant Mouse Monoclonal Antibody [A10G5-R]?

The catalog number for MUC5AC Recombinant Mouse Monoclonal Antibody [A10G5-R] is HA601181.

What sizes are available for MUC5AC Recombinant Mouse Monoclonal Antibody [A10G5-R]?

MUC5AC Recombinant Mouse Monoclonal Antibody [A10G5-R] is available in the following size(s): 100 µL.

Is MUC5AC Recombinant Mouse Monoclonal Antibody [A10G5-R] in stock?

MUC5AC Recombinant Mouse Monoclonal Antibody [A10G5-R] is currently made to order / not held in immediate stock. Contact us for lead time.

What is MUC5AC Recombinant Mouse Monoclonal Antibody [A10G5-R] used for?

What happens if this product doesn’t perform as expected in my experiment?

Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.

Is this product classed as hazardous or restricted for shipping?

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Can you help me confirm if this product is right for my specific experiment?

Yes, contact us with details of your sample type, species, and intended application, and our specialists will confirm suitability or suggest an alternative from our supplier network if this isn’t the best fit.