Superoxide Dismutase 3 Recombinant Rabbit Monoclonal Antibody [JE31-84]

About this product

Extracellular superoxide dismutase [Cu-Zn] is an enzyme that in humans is encoded by the SOD3 gene. This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. The product of this gene is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM. Among black garden ants (Lasius niger), the lifespan of queens is an order of magnitude greater than of workers despite no systematic nucleotide sequence difference between them. The SOD3 gene was found to be the most differentially over-expressed gene in the brains of queen vs worker ants. This finding raises the possibility that SOD3 antioxidant activity plays a key role in the striking longevity of social insect queens.

Specifications

Catalog number

HA721408

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

EC SOD antibody EC-SOD antibody Extracellular superoxide dismutase [Cu Zn] antibody Extracellular superoxide dismutase [Cu-Zn] antibody Extracellular superoxide dismutase antibody Extracellular superoxide dismutase precursor antibody MGC20077 antibody SOD 3 antibody SOD3 antibody SODE_HUMAN antibody Superoxide Dismutase 3 antibody Superoxide dismutase 3 extracellular antibody

Abbreviation

SOD3

Swiss Prot

P08294 Human

Cellular Locus

Secreted, extracellular space, Golgi apparatus, trans-Golgi network.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human Superoxide Dismutase 3 aa 191-240 / 240.

Isotype

IgG

Clone

JE31-84

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB

Positive Control

Human lung tissue lysate, human kidney tissue lysate, human placenta tissue lysate.

Concentration

1 mg/mL

Dilution

WB: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 26 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes