ACTH (Adrenocorticotrophic Hormone) (AH26), CF405S conjugate, 0.1mg/mL

Catalog number BNC040026-500

Price for BNC040026-500

Size / count 1x 500 µL

About this product

ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This MAb is specific to Synacthen (aa1-24 of ACTH) ; does not react with CLIP (aa17-39 of ACTH) . POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs) .It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC040026-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: Pro-opiomelanocortin (POMC) ; Adrenocorticotropin; Adrenocorticotropic hormone; Melanocyte Stimulating Hormone (MSH) ; Melanotropin; beta-Endorphin; Lipotropin; Met-Enkephalin; POC
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: POMC
Gene ID: 5443
NCBI Gene ID: 1897
UniProt: P01189
Swiss Prot: P01189
Host: Mouse
Species Reactivity: Human, Mouse, Rat
Reactivity: ACTH
Immunogen: Synthetic peptide corresponding to aa1-24 of human ACTH
Target Antigen: ACTH
Clonality: Monoclonal
Clone: AH26
Type: Primary
Source: Animal
Origin: Animal
Applications: IF (published) |IHC, FFPE (verified)
Field of Research: Cancer, Endocrinology
Positive Control: Normal pituitary gland or pituitary tumor
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: ACTH is ~5 kDa, and the POMC precursor is ~30 kDa. The molecular weight of POMC depends upon isoform variation and post-translational modifications.
References & Citations: Note: References for this clone sold by other suppliers may be listed for expected applications. Am J Clin Pathol (2014) 141(6): 811-815. (IHC, FFPE) Oncotarget (2017) 8(17): 29282-29299. (IHC, FFPE; IF)
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF405S

Frequently Asked Questions

What is the catalog number for ACTH (Adrenocorticotrophic Hormone) (AH26), CF405S conjugate, 0.1mg/mL?

The catalog number for ACTH (Adrenocorticotrophic Hormone) (AH26), CF405S conjugate, 0.1mg/mL is BNC040026-500.

What sizes are available for ACTH (Adrenocorticotrophic Hormone) (AH26), CF405S conjugate, 0.1mg/mL?

ACTH (Adrenocorticotrophic Hormone) (AH26), CF405S conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is ACTH (Adrenocorticotrophic Hormone) (AH26), CF405S conjugate, 0.1mg/mL in stock?

ACTH (Adrenocorticotrophic Hormone) (AH26), CF405S conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures ACTH (Adrenocorticotrophic Hormone) (AH26), CF405S conjugate, 0.1mg/mL?

ACTH (Adrenocorticotrophic Hormone) (AH26), CF405S conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for ACTH (Adrenocorticotrophic Hormone) (AH26), CF405S conjugate, 0.1mg/mL?

Estimated delivery time for ACTH (Adrenocorticotrophic Hormone) (AH26), CF405S conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for ACTH (Adrenocorticotrophic Hormone) (AH26), CF405S conjugate, 0.1mg/mL?

The safety data sheet for ACTH (Adrenocorticotrophic Hormone) (AH26), CF405S conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is ACTH (Adrenocorticotrophic Hormone) (AH26), CF405S conjugate, 0.1mg/mL used for?

What expression system was used for this recombinant protein?

The expression system, such as E. coli, HEK293, or insect cells, is listed on the datasheet under production details, which can affect post-translational modifications relevant to your application.

Can I return this product if I ordered the wrong one?

As a consumer, you have a 14-day right of withdrawal from receipt under EU consumer protection law, submitted via our withdrawal/cancellation request form. Note this applies to unused, undamaged products, and doesn’t override the expiry/storage conditions on performance-based claims.

Is this product tested for endotoxin levels?

Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.