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Product details

Cytokeratin 8 (KRT8) (rB22.1), CF740 conjugate, 0.1mg/mL

Catalog number BNC742175-100

Price for BNC742175-100

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Size / count 1x 100 µL

About this product

Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18) . CK8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin 8 and 18. CK8 exists on several types of normal and neoplastic epithelia, including many ductal and glandular epithelia such as colon, stomach, small intestine, trachea, and esophagus as well as in transitional epithelium. Anti-CK8 does not react with skeletal muscle or nerve cells. Epithelioid sarcoma, chordoma, and adamantinoma show strong positivity corresponding to that of simple epithelia (with antibodies against CK8, CK18 and CK19) . Reportedly, anti-CK8 is useful for the differentiation of lobular (ring-like, perinuclear) from ductal (peripheral-predominant) carcinoma of the breast. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number
BNC742175-100
Size / count
1x 100 µL
Dry ice
No
Hazardous
No
Discontinued
No
CAS Number
9007-83-4
Synonyms
CARD2; CK8; CYK8; CYKER; Cytokeratin Endo A; DreK8; EndoA; K2C8; K8; Keratin 8; Krt 2.8; KRT8; Type-II Keratin Kb8
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
KRT8
Gene ID
3856
NCBI Gene ID
533782; 708445
UniProt
P05787
Swiss Prot
P05787
Host
Mouse
Species Reactivity
Cow, Human, Pig, Rabbit, Sheep
Reactivity
Cytokeratin 8
Immunogen
Recombinant full-length human KRT8 protein
Target Antigen
Cytokeratin 8
Clonality
Recombinant Monoclonal
Clone
RB22.1
Type
Primary
Source
Animal
Origin
Animal
Applications
IHC, FFPE (verified) |WB (verified)
Field of Research
Cancer, Cytoskeleton
Positive Control
MCF-7 or A431 cells. Skin, Colon, lung or breast carcinoma
Stability
2 years
Concentration
0.1 mg/mL
Buffer
PBS, 0.1% rBSA, 0.05% azide
Molecular Weight
52.5 kDa
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Notes
Protect from light
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment
IgG1
Species
Mus musculus (mouse), Bos taurus (bovine)
Classification
0.05% sodium azide (CAS 26628-22-8)
Conjugate
CF740

Frequently Asked Questions

What is the catalog number for Cytokeratin 8 (KRT8) (rB22.1), CF740 conjugate, 0.1mg/mL?

The catalog number for Cytokeratin 8 (KRT8) (rB22.1), CF740 conjugate, 0.1mg/mL is BNC742175-100.

What sizes are available for Cytokeratin 8 (KRT8) (rB22.1), CF740 conjugate, 0.1mg/mL?

Cytokeratin 8 (KRT8) (rB22.1), CF740 conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is Cytokeratin 8 (KRT8) (rB22.1), CF740 conjugate, 0.1mg/mL in stock?

Cytokeratin 8 (KRT8) (rB22.1), CF740 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Cytokeratin 8 (KRT8) (rB22.1), CF740 conjugate, 0.1mg/mL?

Cytokeratin 8 (KRT8) (rB22.1), CF740 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Cytokeratin 8 (KRT8) (rB22.1), CF740 conjugate, 0.1mg/mL?

Estimated delivery time for Cytokeratin 8 (KRT8) (rB22.1), CF740 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Cytokeratin 8 (KRT8) (rB22.1), CF740 conjugate, 0.1mg/mL?

The safety data sheet for Cytokeratin 8 (KRT8) (rB22.1), CF740 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd02b4061270361e10a92d/msds/bnc742175-100.pdf.

What is Cytokeratin 8 (KRT8) (rB22.1), CF740 conjugate, 0.1mg/mL used for?

Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18) . CK8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in

Can I return this product if I ordered the wrong one?

As a consumer, you have a 14-day right of withdrawal from receipt under EU consumer protection law, submitted via our withdrawal/cancellation request form. Note this applies to unused, undamaged products, and doesn’t override the expiry/storage conditions on performance-based claims.

Is this product tested for endotoxin levels?

Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.

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