Cytokeratin 7/17 (C-46), CF740 conjugate, 0.1mg/mL

Catalog number BNC740949-100

Price for BNC740949-100

Size / count 1x 100 µL

About this product

Recognizes intermediate filament proteins (IFP's) of 55 kDa and 46 kDa, which are identified as cytokeratin 7 and Cytokeratin 17 respectively. On formalin-fixed, paraffin embedded sections, C-46 reacts with keratin 7 only. Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation, which is directly applicable to the characterization of malignant tumors. Cytokeratin 7 is a basic cytokeratin, which is found in most glandular and transitional epithelia but not in the stratified squamous epithelia. Cytokeratin 7 is expressed in the epithelial cells of ovary, lung, and breast but not of colon, prostate, or gastrointestinal tract. Cytokeratin 17 is expressed in epithelial cells of various origins, such as bronchial epithelial cells and skin appendages. Cytokeratin 17 antibody marks basal cell differentiation. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC740949-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: CK-7; K2C7; Keratin 55K Type II Cytoskeletal; Keratin Simple Epithelial Type 1 K7; Keratin Type II Cytoskeletal 7; Krt2-7; KRT7; Sarcolectin; SCL; Type II Mesothelial Keratin K7; Type-II Keratin Kb7; CK17; K17; Keratin Type I Cytoskeletal 17; Keratin-17; KRT17; PCHC1
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: KRT7; KRT17
Gene ID: 3855; 3872
NCBI Gene ID: 411501 ; 2785
UniProt: P08729; Q04695
Swiss Prot: P08729 ; Q04695
Host: Mouse
Species Reactivity: Cow, Human
Reactivity: Cytokeratin 7/17
Immunogen: Cytoskeletal preparation from HeLa cells (human cervical carcinoma cells)
Target Antigen: Cytokeratin 7/17
Clonality: Monoclonal
Clone: C-46
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Field of Research: Cancer, Cytoskeleton
Positive Control: HeLa or ME-180 cells. Skin or hepatocellular carcinoma.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% rBSA, 0.05% azide
Molecular Weight: 55 kDa (CK7) ; 46 kDa (CK17)
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), Bos taurus (bovine)
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF740

Frequently Asked Questions

What is the catalog number for Cytokeratin 7/17 (C-46), CF740 conjugate, 0.1mg/mL?

The catalog number for Cytokeratin 7/17 (C-46), CF740 conjugate, 0.1mg/mL is BNC740949-100.

What sizes are available for Cytokeratin 7/17 (C-46), CF740 conjugate, 0.1mg/mL?

Cytokeratin 7/17 (C-46), CF740 conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is Cytokeratin 7/17 (C-46), CF740 conjugate, 0.1mg/mL in stock?

Cytokeratin 7/17 (C-46), CF740 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Cytokeratin 7/17 (C-46), CF740 conjugate, 0.1mg/mL?

Cytokeratin 7/17 (C-46), CF740 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Cytokeratin 7/17 (C-46), CF740 conjugate, 0.1mg/mL?

Estimated delivery time for Cytokeratin 7/17 (C-46), CF740 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Cytokeratin 7/17 (C-46), CF740 conjugate, 0.1mg/mL?

The safety data sheet for Cytokeratin 7/17 (C-46), CF740 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd02ac061270361e107f22/msds/bnc740949-100.pdf.

What is Cytokeratin 7/17 (C-46), CF740 conjugate, 0.1mg/mL used for?

Do you offer bulk or custom quantities of this product?

Yes. Ordering two or more units, or combining this with other products, usually qualifies for a discount depending on quantity. Contact our sales team with your required volume for a custom quote.

Do you provide a Certificate of Analysis (CoA) for this product?

A Certificate of Analysis is available for most products upon request. Contact our support team with the lot number to obtain the relevant CoA.

Is this product suitable for live cell imaging?

Suitability for live cell imaging depends on the specific reagent and conjugate used. Check the datasheet for imaging-specific validation, or contact us for guidance.