CD95 / FAS / TNFRSF6 (FAS/3588), CF740 conjugate, 0.1mg/mL

Catalog number BNC743588-500

Price for BNC743588-500

Size / count 1x 500 µL

About this product

This MAb specifically recognizes CD95, also known as Fas, a transmembrane glycoprotein with a MW of 40-45 kDa, containing 8 kDa of N-glycoside-linked polysaccharide. It is a receptor for TNFSF6/FASLG, a member of the nerve growth factor receptor/tumor necrosis factor superfamily, mediating receptor-triggered apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation, which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro) . CD95 antigen is expressed on the surface of various cell types, preferentially on the CD45RAlow CD45ROhigh subset of memory T lymphocytes. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC743588-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: ALPS1A; Apoptosis APO1 antigen 1; Apoptosis-mediating surface antigen FAS; APT1; Delta Fas; Fas AMA; Fas cell surface death receptor; FAS1; FASL receptor; FASLG receptor; FASTM; Surface antigen APO1; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6)
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: FAS
Gene ID: 355
NCBI Gene ID: 244139
UniProt: P25445
Swiss Prot: P25445
Host: Mouse
Species Reactivity: Human
Reactivity: CD95|FAS|TNFRSF6
Immunogen: Recombinant fragment (around aa26-96) of human CD95 (FAS) protein (exact sequence is proprietary)
Target Antigen: CD95 | FAS | TNFRSF6
Clonality: Monoclonal
Clone: FAS/3588
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Positive Control: MCF-7 cells (IF/FACS). Human hepatocellular or bladder carcinoma (IHC).
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% rBSA, 0.05% azide
Molecular Weight: 38-50 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG2b, kappa
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF740

Frequently Asked Questions

What is the catalog number for CD95 / FAS / TNFRSF6 (FAS/3588), CF740 conjugate, 0.1mg/mL?

The catalog number for CD95 / FAS / TNFRSF6 (FAS/3588), CF740 conjugate, 0.1mg/mL is BNC743588-500.

What sizes are available for CD95 / FAS / TNFRSF6 (FAS/3588), CF740 conjugate, 0.1mg/mL?

CD95 / FAS / TNFRSF6 (FAS/3588), CF740 conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is CD95 / FAS / TNFRSF6 (FAS/3588), CF740 conjugate, 0.1mg/mL in stock?

CD95 / FAS / TNFRSF6 (FAS/3588), CF740 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures CD95 / FAS / TNFRSF6 (FAS/3588), CF740 conjugate, 0.1mg/mL?

CD95 / FAS / TNFRSF6 (FAS/3588), CF740 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for CD95 / FAS / TNFRSF6 (FAS/3588), CF740 conjugate, 0.1mg/mL?

Estimated delivery time for CD95 / FAS / TNFRSF6 (FAS/3588), CF740 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for CD95 / FAS / TNFRSF6 (FAS/3588), CF740 conjugate, 0.1mg/mL?

The safety data sheet for CD95 / FAS / TNFRSF6 (FAS/3588), CF740 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd029c061270361e102341/msds/bnc743588-500.pdf.

What is CD95 / FAS / TNFRSF6 (FAS/3588), CF740 conjugate, 0.1mg/mL used for?

What should I check when this product first arrives?

Inspect the package immediately for transportation damage, ice loss, leakage, or breakage. Report any issues right away with photos and your order reference; our specialists will determine whether the product is still usable or needs replacing.

Does this cell line or biologic require a Material Transfer Agreement (MTA)?

Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.