CD11a (Cris-3), CF488A conjugate, 0.1mg/mL

About this product

Recognizes a protein of 180 kDa, identified as CD11a (Leucocyte Workshop II; Code N202) . CD11a complex with the 2 subunit of the integrin family, CD18, to form the cell surface heterodimer, LFA-1 or CD11a /C18 (aLbL) . LFA-1 is expressed on all leukocytes including lymphocytes, monocytes, and granulocytes. It is involved in leukocyte adhesion to its ligands including intercellular adhesion molecule-1 (ICAM-1 or CD54), ICAM-2 (CD102), ICAM-3 (CD50) and Telencephalin (TLN) and play a role in most immune/inflammatory responses.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNC880151-500

Size / count

1x 500 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

Antigen CD11A (p180), lymphocyte function associated antigen 1, alpha polypeptide; Integrin alpha-L; ITGAL; Leukocyte Adhesion Glycoprotein LFA1 Alpha Chain; LFA 1 alpha (LFA1A) ; Ly15; Ly21; p180

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

ITGAL

Gene ID

3683

NCBI Gene ID

174103

UniProt

P20701

Swiss Prot

P20701

Host

Mouse

Species Reactivity

Human

Reactivity

CD11a

Immunogen

Stimulated human leukocytes

Target Antigen

CD11a

Clonality

Monoclonal

Clone

Cris-3

Type

Primary

Source

Animal

Origin

Animal

Applications

Flow (verified) |Functional studies (published)

Field of Research

Immunology

Positive Control

JY, HUT-78, MOLT-4, HL60, U937, and human leukocytes. Human lymph nodes and tonsils.

Stability

2 years

Concentration

0.1 mg/mL

Buffer

PBS, 0.1% BSA, 0.05% azide

Molecular Weight

180 kDa

References & Citations

Note: References for this clone sold by other suppliers may be listed for expected applications. Knapp W. et al. Leukocyte Typing IV, Oxford Unioversity Press, Oxford, 1989. Reinherz EL et al. eds. Leukocyte Typing II, Oxford University Press, Oxford, 1985. J Exp Med (1990) 172: 335-345. (Flow, surface) Am J Physiol Cell Physiol (1998) 274(6): C1634-C1644. (receptor blockade).

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Notes

Protect from light

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG2b, kappa

Species

Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

Classification

0.05% sodium azide (CAS 26628-22-8)

Conjugate

CF488A