CD171 / L1CAM (L1 Cell Adhesion Molecule) (UJ127), 0.2mg/mL

About this product

Recognizes a cell surface protein of 220-240 kDa, identified as L1 cell adhesion molecule. The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius) ; 2) MASA (mental retardation, aphasia, shuffling gait, and adducted thumbs) ; and 3) SPG1 (spastic paraplegia) . The L1, neural cell adhesion molecule (L1CAM) also plays an important role in axon growth, fasciculation, and neural migration as well as in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm. This MAb is useful in the identification of primitive neuroectodermal tumors. It binds to tumors of neuroectodermal and glial origin e.g. neuroblastoma and Schwannomas. It does not bind to pediatric or adult brain.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNUB0679-100

Size / count

1x 100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

CAML1, HSAS1, Hyd, L1 Cell Adhesion Molecule, L1-NCAM, MASA, MIC5, NCAM-L1, Nerve-growth factor-inducible large external glycoprotein, Neural cell adhesion molecule L1, NILE, S10, SPG1

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

L1CAM

Gene ID

3897

NCBI Gene ID

52818

UniProt

P32004

Swiss Prot

P32004

Host

Mouse

Species Reactivity

Human

Reactivity

CD171|L1CAM

Immunogen

Homogenous suspension of 16 week human fetal brain

Target Antigen

CD171 | L1CAM

Clonality

Monoclonal

Clone

UJ127

Type

Primary

Source

Animal

Origin

Animal

Applications

Flow, surface (published) |IHC, FFPE (published) |IP (published) |WB (published)

Field of Research

Cancer, Cell adhesion, Developmental biology

Positive Control

Neuroblastomas or Schwannomas

Stability

2 years

Concentration

0.2 mg/mL

Buffer

PBS, 0.05% BSA, 0.05% azide

Molecular Weight

220-240 kDa

References & Citations

Note: References for this clone sold by other suppliers may be listed for expected applications. Eur J Gynaecol Oncol (2008) 29(1):26-30. (IHC, FFPE; WB) Anticancer Res (2009) 29: 1195-1200. (IHC, FFPE) Mol Biol Cell (2010) 21: 1671-1685. (IHC, FFPE; Flow, IP)

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG1, kappa

Species

Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

Classification

PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)

Conjugate

Purified, with BSA