Smg1 Recombinant Rabbit Monoclonal Antibody [JE38-38]

Catalog number HA722452

Price for HA722452

Size / count 100 µL

About this product

Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ.

Specifications

Catalog number: HA722452
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: 61E3.4 antibody ATX antibody hSMG-1 antibody hSMG1 antibody KIAA0421 antibody Lambda interacting protein antibody Lambda-interacting protein antibody Lambda/iota protein kinase C interacting protein antibody Lambda/iota protein kinase C-interacting protein antibody LIP antibody Phosphatidylinositol 3 kinase related kinase antibody Phosphatidylinositol 3 kinase related protein kinase antibody PI 3 kinase related kinase SMG 1 antibody Serine/threonine protein kinase SMG1 antibody Serine/threonine-protein kinase SMG1 antibody SMG-1 antibody smg1 antibody SMG1_HUMAN antibody
Abbreviation: Serine/threonine-protein kinase SMG1 SMG-1; hSMG-1 Lambda/iota protein kinase C-interacting protein Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1 SMG1 ATX KIAA0421 LIP
Swiss Prot: Q96Q15 Human, Q8BKX6 Mouse,
Cellular Locus: Cytoplasm. Nucleus.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein within Human Smg1 aa 3,562-3,661 / 3,661.
Isotype: IgG
Clone: JE38-38
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB
Positive Control: HEK-293 cell lysate, MCF7 cell lysate, C2C12 cell lysate, C6 cell lysate, COS-1 cell lysate.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 410 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for Smg1 Recombinant Rabbit Monoclonal Antibody [JE38-38]?

The catalog number for Smg1 Recombinant Rabbit Monoclonal Antibody [JE38-38] is HA722452.

What sizes are available for Smg1 Recombinant Rabbit Monoclonal Antibody [JE38-38]?

Smg1 Recombinant Rabbit Monoclonal Antibody [JE38-38] is available in the following size(s): 100 µL.

Is Smg1 Recombinant Rabbit Monoclonal Antibody [JE38-38] in stock?

Smg1 Recombinant Rabbit Monoclonal Antibody [JE38-38] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Smg1 Recombinant Rabbit Monoclonal Antibody [JE38-38] used for?

What happens if this product doesn’t perform as expected in my experiment?

Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.

Is this product classed as hazardous or restricted for shipping?

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Can you help me confirm if this product is right for my specific experiment?

Yes, contact us with details of your sample type, species, and intended application, and our specialists will confirm suitability or suggest an alternative from our supplier network if this isn’t the best fit.