P14ARF (4C6/4), CF740 conjugate, 0.1mg/mL

Catalog number BNC742088-100

Price for BNC742088-100

Size / count 1x 100 µL

About this product

The progression of cells through the cell cycle is regulated by a family of proteins designated cyclin-dependent kinases (Cdks) . Sequential activation of individual members of this family and their consequent phosphorylation of critical substrates promotes orderly progression through the cell cycle. Multiple proteins are encoded by the tumor suppressor gene CDKN2A (MTS1/ p16INK4a) via translation of alternate reading frames, resulting in the pro- duction of the p19 ARF protein in mice and the p14 ARF protein in humans. p14 ARF induces an increase in MDM2 and p21 levels and leads to cell cycle arrest in both G1 and G2/M. p14 ARF is negatively regulated by p53 and is known to bind directly to MDM2. CDKN2A also encodes the mitotic protein p16, which binds to and inhibits the Cdk4/cyclin D complex. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC742088-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: ARF; CDK4 inhibitor p16 INK4; CDK4I; CDKN2; CDKN2A; Cell cycle negative regulator beta; CMM2; Cyclin dependent kinase 4 inhibitor A; Cyclin dependent kinase inhibitor 2A; INK4; INK4a; Melanoma p16 inhibits CDK4; MLM; MTS 1; MTS1; Multiple tumor suppressor 1; p14; p16; p16 INK4a; p16INK4a; p19; P19ARF; TP16
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: ARF
Gene ID: 1029
NCBI Gene ID: 512599
UniProt: P42771
Swiss Prot: P42771
Host: Mouse
Species Reactivity: Human, Rat
Reactivity: P14ARF
Immunogen: Recombinant full-length human p14 ARF protein
Target Antigen: p14ARF
Clonality: Monoclonal
Clone: 4C6/4
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Positive Control: MCF7, H1299 and HeLa cells; human prostate carcinoma.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% rBSA, 0.05% azide
Molecular Weight: 14 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG2a, kappa
Species: Mus musculus (mouse), Bos taurus (bovine)
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF740

Frequently Asked Questions

What is the catalog number for P14ARF (4C6/4), CF740 conjugate, 0.1mg/mL?

The catalog number for P14ARF (4C6/4), CF740 conjugate, 0.1mg/mL is BNC742088-100.

What sizes are available for P14ARF (4C6/4), CF740 conjugate, 0.1mg/mL?

P14ARF (4C6/4), CF740 conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is P14ARF (4C6/4), CF740 conjugate, 0.1mg/mL in stock?

P14ARF (4C6/4), CF740 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures P14ARF (4C6/4), CF740 conjugate, 0.1mg/mL?

P14ARF (4C6/4), CF740 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for P14ARF (4C6/4), CF740 conjugate, 0.1mg/mL?

Estimated delivery time for P14ARF (4C6/4), CF740 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for P14ARF (4C6/4), CF740 conjugate, 0.1mg/mL?

The safety data sheet for P14ARF (4C6/4), CF740 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd029f061270361e103539/msds/bnc742088-100.pdf.

What is P14ARF (4C6/4), CF740 conjugate, 0.1mg/mL used for?

What is the purity of this recombinant protein?

Purity, typically assessed by SDS-PAGE, is listed on the datasheet under quality control data.

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.