CD46 (122.2), 1mg/mL

Catalog number BNUM0175-50

Price for BNUM0175-50

Size / count 1x 50 µL

About this product

CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4 into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNUM0175-50
Size / count: 1x 50 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: AHUS2; Complement membrane cofactor protein; MCP; Measles virus receptor; Membrane cofactor protein; MIC10; TLX; Trophoblast leucocyte common antigen; Trophoblast lymphocyte cross reactive antigen
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: CD46
Gene ID: 4179
NCBI Gene ID: 510402
UniProt: P15529
Swiss Prot: P15529
Host: Mouse
Species Reactivity: Human
Reactivity: CD46
Immunogen: Recombinant human CD46 protein
Target Antigen: CD46
Clonality: Monoclonal
Clone: 122.2
Type: Primary
Source: Animal
Origin: Animal
Applications: Flow (verified) |Flow, surface (published)
Field of Research: Immunology
Positive Control: HeLa, K-562 or MOLT-4 cells. Kidney
Stability: 2 years
Concentration: 1 mg/mL
Buffer: PBS, no BSA, no azide
Molecular Weight: 56-66 kDa
References & Citations: Note: References for this clone sold by other suppliers may be listed for expected applications. Virology (2002) 300: 160-169. (Flow, surface)
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse)
Classification: PBS, no BSA, no sodium azide (CAS 26628-22-8)
Conjugate: Purified, BSA-free

Frequently Asked Questions

What is the catalog number for CD46 (122.2), 1mg/mL?

The catalog number for CD46 (122.2), 1mg/mL is BNUM0175-50.

What sizes are available for CD46 (122.2), 1mg/mL?

CD46 (122.2), 1mg/mL is available in the following size(s): 1x 50 µL.

Is CD46 (122.2), 1mg/mL in stock?

CD46 (122.2), 1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures CD46 (122.2), 1mg/mL?

CD46 (122.2), 1mg/mL is manufactured by Biotium.

What is the estimated delivery time for CD46 (122.2), 1mg/mL?

Estimated delivery time for CD46 (122.2), 1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for CD46 (122.2), 1mg/mL?

The safety data sheet for CD46 (122.2), 1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is CD46 (122.2), 1mg/mL used for?

Can you help me confirm if this product is right for my specific experiment?

Yes, contact us with details of your sample type, species, and intended application, and our specialists will confirm suitability or suggest an alternative from our supplier network if this isn’t the best fit.

What is the purity of this recombinant protein?

Purity, typically assessed by SDS-PAGE, is listed on the datasheet under quality control data.

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.