CD46 (122.2), CF594 conjugate, 0.1mg/mL

Catalog number BNC940175-500

Price for BNC940175-500

Size / count 1x 500 µL

About this product

CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4 into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC940175-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: AHUS2; Complement membrane cofactor protein; MCP; Measles virus receptor; Membrane cofactor protein; MIC10; TLX; Trophoblast leucocyte common antigen; Trophoblast lymphocyte cross reactive antigen
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: CD46
Gene ID: 4179
NCBI Gene ID: 510402
UniProt: P15529
Swiss Prot: P15529
Host: Mouse
Species Reactivity: Human
Reactivity: CD46
Immunogen: Recombinant human CD46 protein
Target Antigen: CD46
Clonality: Monoclonal
Clone: 122.2
Type: Primary
Source: Animal
Origin: Animal
Applications: Flow (verified) |Flow, surface (published)
Field of Research: Immunology
Positive Control: HeLa, K-562 or MOLT-4 cells. Kidney
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 56-66 kDa
References & Citations: Note: References for this clone sold by other suppliers may be listed for expected applications. Virology (2002) 300: 160-169. (Flow, surface)
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF594

Frequently Asked Questions

What is the catalog number for CD46 (122.2), CF594 conjugate, 0.1mg/mL?

The catalog number for CD46 (122.2), CF594 conjugate, 0.1mg/mL is BNC940175-500.

What sizes are available for CD46 (122.2), CF594 conjugate, 0.1mg/mL?

CD46 (122.2), CF594 conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is CD46 (122.2), CF594 conjugate, 0.1mg/mL in stock?

CD46 (122.2), CF594 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures CD46 (122.2), CF594 conjugate, 0.1mg/mL?

CD46 (122.2), CF594 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for CD46 (122.2), CF594 conjugate, 0.1mg/mL?

Estimated delivery time for CD46 (122.2), CF594 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for CD46 (122.2), CF594 conjugate, 0.1mg/mL?

The safety data sheet for CD46 (122.2), CF594 conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is CD46 (122.2), CF594 conjugate, 0.1mg/mL used for?

How many freeze-thaw cycles can this product tolerate?

We recommend aliquoting the product upon receipt to avoid repeated freeze-thaw cycles, which can reduce activity and stability. This is your responsibility once the product has been delivered.

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.

What temperature does this product ship at?

Shipping temperature is chosen based on the product’s stability needs, ranging from ambient to dry ice, and is indicated on the product page. Any related shipping fee is shown clearly in your quotation.