CD46 (197-2B1), CF488A conjugate, 0.1mg/mL

About this product

Recognizes a protein of 52 kDa-58 kDa, identified as CD46 (also known as membrane cofactor protein, MCP) . CD46 exists as many isoforms in a variety of tissues. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. CD46 functions as a C3b/C4b-binding glycoprotein that inhibits complement activation on host cells. It also serves as a measles virus receptor, an adherence factor for group A Streptococcus pyogenes, and a cellular pilus receptor for pathogenic Neisseria. This MAb can be applied to test complement activation in pseudo-allergic reactions to acetylsalicylic acid and to test for measles virus infection of cells.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNC880931-500

Size / count

1x 500 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

AHUS2; Complement membrane cofactor protein; MCP; Measles virus receptor; Membrane cofactor protein; MIC10; TLX; Trophoblast leucocyte common antigen; Trophoblast lymphocyte cross reactive antigen

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

CD46

Gene ID

4179

NCBI Gene ID

510402

UniProt

P15529

Swiss Prot

P15529

Host

Mouse

Species Reactivity

Human

Reactivity

CD46

Immunogen

Stimulated human leukocytes

Target Antigen

CD46

Clonality

Monoclonal

Clone

197-2B1

Type

Primary

Source

Animal

Origin

Animal

Applications

Flow, surface (published) |Functional studies (published)

Field of Research

Immunology

Positive Control

K562, U937, HL60, HeLa and Jurkat cells, and human lymphocytes. Lymph node and tonsil.

Stability

2 years

Concentration

0.1 mg/mL

Buffer

PBS, 0.1% BSA, 0.05% azide

Molecular Weight

52-58 kDa

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Notes

Protect from light

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG2a, kappa

Species

Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

Classification

0.05% sodium azide (CAS 26628-22-8)

Conjugate

CF488A