CD59 (heavy chain of Protectin) (BRA-10G), 0.2mg/mL

Catalog number BNUB0181-100

Price for BNUB0181-100

Size / count 1x 100 µL

About this product

Reacts with human CD59, a 20 kDa glycosyl phosphatidyl-inositol (GPI) -anchored cell surface protein. CD59 regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. CD59 is widely distributed on cells in all tissues. It inhibits formation of MAC, thus protecting cells from complement-mediated lysis. The expression of CD59 on erythrocytes is important for their survival. Genetic defects in GPI-anchor attachment, that cause a reduction or loss of CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal hemoglobinuria (PNH) . This MAb is useful for study on GPI-anchored proteins, PNH and CD59 functions.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNUB0181-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: 20kDa homologous restriction factor (HRF20) ; Complement regulatory protein; Human leukocyte antigen MIC11; MAC-inhibitory protein (MACIP) ; Membrane attack complex inhibition factor (MACIF) ; Membrane inhibitor of reactive lysis; MIRL; MSK21; Protectin; T cell activating protein
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: CD59
Gene ID: 966
NCBI Gene ID: 278573; 709466; 710641
UniProt: P13987
Swiss Prot: P13987
Host: Mouse
Species Reactivity: Human
Reactivity: CD59
Immunogen: Human K562 tumor cells
Target Antigen: CD59
Clonality: Monoclonal
Clone: BRA-10G
Type: Primary
Source: Animal
Origin: Animal
Applications: Flow, surface (published) |IP (published) |WB (published)
Field of Research: Hematology, Immunology
Positive Control: Daudi, CEM, K562, HPB.ALL, Jurkat, Raji, and human lymphocytes. Human lymph node and tonsil.
Stability: 2 years
Concentration: 0.2 mg/mL
Buffer: PBS, 0.05% BSA, 0.05% azide
Molecular Weight: 20 kDa
References & Citations: Note: References for this clone sold by other suppliers may be listed for expected applications. Neoplasma (1992) 39(6),325-9. (surface Flow, IP) Diabetes (2002) 51(12), 3499-3504. (IP) Infection Immunity (2006) 74(2):1189-1195. (WB blot) Leukocyte Typing V (S F Schlossman, et al, eds.) Oxford University Press, Oxford (1995) p. 1476-1477.
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)
Conjugate: Purified, with BSA

Frequently Asked Questions

What is the catalog number for CD59 (heavy chain of Protectin) (BRA-10G), 0.2mg/mL?

The catalog number for CD59 (heavy chain of Protectin) (BRA-10G), 0.2mg/mL is BNUB0181-100.

What sizes are available for CD59 (heavy chain of Protectin) (BRA-10G), 0.2mg/mL?

CD59 (heavy chain of Protectin) (BRA-10G), 0.2mg/mL is available in the following size(s): 1x 100 µL.

Is CD59 (heavy chain of Protectin) (BRA-10G), 0.2mg/mL in stock?

CD59 (heavy chain of Protectin) (BRA-10G), 0.2mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures CD59 (heavy chain of Protectin) (BRA-10G), 0.2mg/mL?

CD59 (heavy chain of Protectin) (BRA-10G), 0.2mg/mL is manufactured by Biotium.

What is the estimated delivery time for CD59 (heavy chain of Protectin) (BRA-10G), 0.2mg/mL?

Estimated delivery time for CD59 (heavy chain of Protectin) (BRA-10G), 0.2mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for CD59 (heavy chain of Protectin) (BRA-10G), 0.2mg/mL?

The safety data sheet for CD59 (heavy chain of Protectin) (BRA-10G), 0.2mg/mL is available here: https://cdn.gentaur.com/products/37/68dd0298061270361e100ec4/msds/bnub0181-100.pdf.

What is CD59 (heavy chain of Protectin) (BRA-10G), 0.2mg/mL used for?

What expression system was used for this recombinant protein?

The expression system, such as E. coli, HEK293, or insect cells, is listed on the datasheet under production details, which can affect post-translational modifications relevant to your application.

Can I return this product if I ordered the wrong one?

As a consumer, you have a 14-day right of withdrawal from receipt under EU consumer protection law, submitted via our withdrawal/cancellation request form. Note this applies to unused, undamaged products, and doesn’t override the expiry/storage conditions on performance-based claims.

Is this product tested for endotoxin levels?

Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.