CD59 (heavy chain of Protectin) (MACIF/1193), 1mg/mL

Catalog number BNUM1193-50

Price for BNUM1193-50

Size / count 1x 50 µL

About this product

Reacts with human CD59, a 20 kDa glycosyl phosphatidyl-inositol (GPI) -anchored cell surface protein. CD59 regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. CD59 is widely distributed on cells in all tissues. It inhibits formation of MAC, thus protecting cells from complement-mediated lysis. The expression of CD59 on erythrocytes is important for their survival. Genetic defects in GPI-anchor attachment, that cause a reduction or loss of CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal hemoglobinuria (PNH) . It is useful for study on GPI-anchored proteins, PNH and CD59 functions.This antibody is available purified with BSA/azide at 200 ug/mL, or BSA/azide-free at 1 mg/mL.

Specifications

Catalog number: BNUM1193-50
Size / count: 1x 50 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: 20kDa homologous restriction factor (HRF20) ; Complement regulatory protein; Human leukocyte antigen MIC11; MAC-inhibitory protein (MACIP) ; Membrane attack complex inhibition factor (MACIF) ; Membrane inhibitor of reactive lysis; MIRL; MSK21; Protectin; T cell activating protein
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: CD59
Gene ID: 966
NCBI Gene ID: 278573; 709466; 710641
UniProt: P13987
Swiss Prot: P13987
Host: Mouse
Species Reactivity: Human
Reactivity: CD59
Immunogen: Recombinant full-length human CD59 protein
Target Antigen: CD59
Clonality: Monoclonal
Clone: MACIF/1193
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Field of Research: Hematology, Immunology
Positive Control: Daudi, CEM, K562, HPB.ALL, Jurkat, Raji, and human lymphocytes. Human lymph node and tonsil.
Stability: 2 years
Concentration: 1 mg/mL
Buffer: PBS, no BSA, no azide
Molecular Weight: 20 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgM, kappa
Species: Mus musculus (mouse)
Classification: PBS, no BSA, no sodium azide (CAS 26628-22-8)
Conjugate: Purified, BSA-free

Frequently Asked Questions

What is the catalog number for CD59 (heavy chain of Protectin) (MACIF/1193), 1mg/mL?

The catalog number for CD59 (heavy chain of Protectin) (MACIF/1193), 1mg/mL is BNUM1193-50.

What sizes are available for CD59 (heavy chain of Protectin) (MACIF/1193), 1mg/mL?

CD59 (heavy chain of Protectin) (MACIF/1193), 1mg/mL is available in the following size(s): 1x 50 µL.

Is CD59 (heavy chain of Protectin) (MACIF/1193), 1mg/mL in stock?

CD59 (heavy chain of Protectin) (MACIF/1193), 1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures CD59 (heavy chain of Protectin) (MACIF/1193), 1mg/mL?

CD59 (heavy chain of Protectin) (MACIF/1193), 1mg/mL is manufactured by Biotium.

What is the estimated delivery time for CD59 (heavy chain of Protectin) (MACIF/1193), 1mg/mL?

Estimated delivery time for CD59 (heavy chain of Protectin) (MACIF/1193), 1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for CD59 (heavy chain of Protectin) (MACIF/1193), 1mg/mL?

The safety data sheet for CD59 (heavy chain of Protectin) (MACIF/1193), 1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is CD59 (heavy chain of Protectin) (MACIF/1193), 1mg/mL used for?

Can this product be used in multiplex assays?

Multiplex compatibility depends on the specific product and detection panel. Contact our technical support team with details of your multiplex system for guidance before ordering.

What happens if this product doesn’t perform as expected in my experiment?

Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.

Is this product classed as hazardous or restricted for shipping?

Some products are subject to special import/export regulations, dangerous goods handling, or licensing requirements. Where this applies, it’s noted on the product page, and any required extra documents or fees will be confirmed with you before dispatch, never added without your consent.