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![Ionotropic glutamate receptor 2 + 3 Recombinant Rabbit Monoclonal Antibody [JE33-28] — image 1 of 1](https://cdn.genprice.uk/products/992/68dd1c8c061270361ea81a18/imageurl/ha721405.webp)
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Product details
Catalog number HA721405
Price for HA721405
Size / count 100 µL
Glutamate ionotropic receptor AMPA type subunit 2 (Glutamate receptor 2, or GluR-2) is a protein that in humans is encoded by the GRIA2 (or GLUR2) gene and it is a subunit found in the AMPA receptors. Glutamate receptor 3 is a protein that in humans is encoded by the GRIA3 gene. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. GRIA2 product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), called AMPA receptors, and function as ligand-activated cation channels. These channels are assembled from a combination of 4 subunits, encoded by 4 genes (GRIA1-4). The subunit encoded by this gene (GRIA2) is subject to RNA editing which renders the receptor that it becomes part of impermeable to calcium ions (Ca2+). Human and animal studies suggest that the RNA editing is essential for normal brain function, and defective RNA editing of GRIA2 may be relevant to the etiology of amyotrophic lateral sclerosis (ALS). Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for GRIA2, which includes the generation of flip and flop isoforms that vary in their signal transduction properties. Genome studies have uncovered a tentative link between defective GRIA3 variants and a highly elevated risk of schizophrenia.
The catalog number for Ionotropic glutamate receptor 2 + 3 Recombinant Rabbit Monoclonal Antibody [JE33-28] is HA721405.
Ionotropic glutamate receptor 2 + 3 Recombinant Rabbit Monoclonal Antibody [JE33-28] is available in the following size(s): 100 µL.
Ionotropic glutamate receptor 2 + 3 Recombinant Rabbit Monoclonal Antibody [JE33-28] is currently made to order / not held in immediate stock. Contact us for lead time.
Glutamate ionotropic receptor AMPA type subunit 2 (Glutamate receptor 2, or GluR-2) is a protein that in humans is encoded by the GRIA2 (or GLUR2) gene and it is a subunit found in the AMPA receptors. Glutamate receptor 3 is a protein that in humans is encoded by the GRIA3 gene. Glutamate receptors
Post-reconstitution storage guidance is listed on the datasheet, typically requiring aliquoting and storage at -20°C or -80°C to preserve activity.
Multiplex compatibility depends on the specific product and detection panel. Contact our technical support team with details of your multiplex system for guidance before ordering.
Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.
