Pyrin Recombinant Rabbit Monoclonal Antibody [PSH06-12]

Catalog number HA722509

Price for HA722509

Size / count 100 µL

About this product

Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation. However, it can also have a positive effect in the inflammatory pathway, acting as an innate immune sensor that triggers PYCARD/ASC specks formation, caspase-1 activation, and IL1B and IL18 production. Together with AIM2, also acts as a mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, in response to bacterial infection. It is required for PSTPIP1-induced PYCARD/ASC oligomerization and inflammasome formation. Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization.

Specifications

Catalog number: HA722509
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: FMF antibody Marenostrin antibody Mediterranean fever antibody Mediterranean fever protein antibody MEF antibody Mefv antibody MEFV_HUMAN antibody Pyrin antibody TRIM20 antibody
Abbreviation: Pyrin Marenostrin MEFV MEF, TRIM20
Swiss Prot: O15553 Human
Cellular Locus: Cell projection. Cytoplasm. Cytoskeleton. Microtubule. Nucleus.
Host: Rabbit
Species Reactivity: Human
Immunogen: Recombinant protein within Human Pyrin aa 450-781.
Isotype: IgG
Clone: PSH06-12
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, FC
Positive Control: THP-1 cell lysate, THP-1 treated with 1μg/mL LPS for 24 hours cell lysate, THP-1.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000 ;FC: 1:1,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 86 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for Pyrin Recombinant Rabbit Monoclonal Antibody [PSH06-12]?

The catalog number for Pyrin Recombinant Rabbit Monoclonal Antibody [PSH06-12] is HA722509.

What sizes are available for Pyrin Recombinant Rabbit Monoclonal Antibody [PSH06-12]?

Pyrin Recombinant Rabbit Monoclonal Antibody [PSH06-12] is available in the following size(s): 100 µL.

Is Pyrin Recombinant Rabbit Monoclonal Antibody [PSH06-12] in stock?

Pyrin Recombinant Rabbit Monoclonal Antibody [PSH06-12] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Pyrin Recombinant Rabbit Monoclonal Antibody [PSH06-12] used for?

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.

What is the difference between this product and a similar catalogue number?

Differences typically involve clone, conjugate, host species, or validated applications. Compare the respective datasheets, or contact us with both catalogue numbers for a direct comparison.

Do you offer custom or private-label production of this type of product?

Yes, custom antibody development and private-label production services are available. Contact our sales team to discuss your target, timeline, and quantity requirements.