CD71 (66IG10), 0.2mg/mL

About this product

This antibody recognizes a ~90-95 kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190 kDa. This MAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Its epitope is localized in the extracellular domain of CD71. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. CD71/Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNUB0871-500

Size / count

1x 500 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

Mtvr-1, p90, TFR1, TFRC transferrin receptor (p90 CD71), TRFR

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

TFRC

Gene ID

7037

NCBI Gene ID

529618

UniProt

P02786

Swiss Prot

P02786

Host

Mouse

Species Reactivity

Human

Reactivity

CD71|Transferrin Receptor

Immunogen

Human thymocytes (T-cells)

Target Antigen

CD71 | Transferrin Receptor

Clonality

Monoclonal

Clone

66IG10

Type

Primary

Source

Animal

Origin

Animal

Applications

Flow, surface (published) |IF (published) |Flow, surface (verified) |IP (published)

Field of Research

Cancer

Positive Control

CCRF-CEM, Jurkat or K-562. Human placenta or breast carcinoma.

Stability

2 years

Concentration

0.2 mg/mL

Buffer

PBS, 0.05% BSA, 0.05% azide

Molecular Weight

85-95 kDa (monomer) ; 190 kDa (dimer)

References & Citations

Note: References for this clone sold by other suppliers may be listed for expected applications. J Immunol (1999) 162: 1488-1495. (cell internalization; IF) J Virol (2001) 75(24): 12347-12358. (Flow, surface) PNAS USA (2003) 100(20): 11583-11588. (IP) Mol Biol Cell (2003) 14(12): 4745-5124. (cell internalization; IP)

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG1, kappa

Species

Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

Classification

PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)

Conjugate

Purified, with BSA