CD86 (BU63), CF405S conjugate, 0.1mg/mL — image 1 of 2

Product details

CD86 (BU63), CF405S conjugate, 0.1mg/mL

Catalog number BNC040193-100

Price for BNC040193-100

Size / count 1x 100 µL

About this product

Recognizes a protein of 70 kDa, which is identified as CD86. CD86, along with CD80/B71, is an important accessory molecule in T cell co-stimulation via its interaction with CD28 and CD152/CTLA4, a cancer immunotherapy target. It is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is expressed at high levels on resting peripheral monocytes and dendritic cells and at very low density on resting B and T lymphocytes. CD86 expression is rapidly upregulated by B cell specific stimuli with peak expression at 18 to 42 hours after stimulation. Since CD86 has rapid kinetics of induction, it is believed to be the major CD28 ligand expressed early in the immune response. It is also found on malignant Hodgkin and Reed Sternberg (HRS) cells in Hodgkin's disease. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC040193-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: Activation B7-2 antigen|B lymphocyte activation antigen B72|CD28 antigen ligand 2|CD28LG2|CLS1|CTLA-4 counter-receptor B7.2|Early T-cell co-stimulatory molecule 1|ETC-1|FUN-1|LAB72|Ly-58|MB7-2|TS/A-2
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: CD86
Gene ID: 942
NCBI Gene ID: 171182
UniProt: P42081
Swiss Prot: P42081
Host: Mouse
Species Reactivity: Human, Mouse, Rat
Reactivity: CD86
Immunogen: ARH-77 (B-lymphoblastoid cell line)
Target Antigen: CD86
Clonality: Monoclonal
Clone: BU63
Type: Primary
Source: Animal
Origin: Animal
Applications: Flow (verified) |Flow, surface (published) |Functional studies (published) |IF (verified) |IHC, FFPE (verified)
Field of Research: Cancer immunotherapy/immune checkpoint, Immunology
Positive Control: 293T or Jukat cells. Monocytes and dendritic cells, activated T, B and natural killer cells in lymph node or tonsil.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 70 kDa
References & Citations: Note: References for this clone sold by other suppliers may be listed for expected applications. J Immunol (1998) 161: 6375-6382. (functional studies; Flow, surface)
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF405S

Frequently Asked Questions

What is the catalog number for CD86 (BU63), CF405S conjugate, 0.1mg/mL?

The catalog number for CD86 (BU63), CF405S conjugate, 0.1mg/mL is BNC040193-100.

What sizes are available for CD86 (BU63), CF405S conjugate, 0.1mg/mL?

CD86 (BU63), CF405S conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is CD86 (BU63), CF405S conjugate, 0.1mg/mL in stock?

CD86 (BU63), CF405S conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures CD86 (BU63), CF405S conjugate, 0.1mg/mL?

CD86 (BU63), CF405S conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for CD86 (BU63), CF405S conjugate, 0.1mg/mL?

Estimated delivery time for CD86 (BU63), CF405S conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for CD86 (BU63), CF405S conjugate, 0.1mg/mL?

The safety data sheet for CD86 (BU63), CF405S conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is CD86 (BU63), CF405S conjugate, 0.1mg/mL used for?

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.

Is this antibody conjugated?

Conjugation status, such as unconjugated, HRP, FITC, or biotin, is specified in the product name and confirmed on the datasheet.

What is the sensitivity of this ELISA kit?

Assay sensitivity, including the minimum detectable dose, is listed on the datasheet. Kits that are assembled on order typically ship within 2-4 weeks.