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Product details
Catalog number BNC471098-500
Price for BNC471098-500
Size / count 1x 500 µL
This antibody recognizes a protein of 55-62 kDa, identified as cyclin B1. In mammals, cyclin B associates with inactive p34cdc2, which facilitates phosphorylation of p34cdc2 at aa 14Thr and 15Tyr. This maintains the inactive state until the end of G2-phase. The inactive cyclin B-p34cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis, when Cdc25, a specific protein phosphatase, dephosphorylates aa 14Thr and 15Tyr of p34cdc2 rendering the complex active at the G2/M boundary. This mitotic kinase complex remains active until the metaphase/anaphase transition when cyclin B is degraded. This degradation process is ubiquitin-dependent and is necessary for the cell to exit mitosis. So, cyclin B-p34cdc2 plays a critical role in G2 to M transition. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
The catalog number for Cyclin B1 (CCNB1/1098), CF647 conjugate, 0.1mg/mL is BNC471098-500.
Cyclin B1 (CCNB1/1098), CF647 conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.
Cyclin B1 (CCNB1/1098), CF647 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.
Cyclin B1 (CCNB1/1098), CF647 conjugate, 0.1mg/mL is manufactured by Biotium.
Estimated delivery time for Cyclin B1 (CCNB1/1098), CF647 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.
The safety data sheet for Cyclin B1 (CCNB1/1098), CF647 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd029a061270361e10151c/msds/bnc471098-500.pdf.
This antibody recognizes a protein of 55-62 kDa, identified as cyclin B1. In mammals, cyclin B associates with inactive p34cdc2, which facilitates phosphorylation of p34cdc2 at aa 14Thr and 15Tyr. This maintains the inactive state until the end of G2-phase. The inactive cyclin B-p34cdc2 complex cont
The formulation or storage buffer is listed on the product datasheet. If you require a carrier-free or custom formulation, contact us before ordering, as this may involve a made-to-order production timeline.
A starting IHC dilution range is listed on the datasheet, but should be optimized for your specific tissue type and staining protocol.
Yes, safety data sheets are available for hazardous or chemically classified products and can be provided on request or downloaded from the product page.
