Cyclin D1 (DCS-6), Biotin conjugate, 0.1mg/mL — image 1 of 3

Product details

Cyclin D1 (DCS-6), Biotin conjugate, 0.1mg/mL

Catalog number BNCB0007-100

Price for BNCB0007-100

Size / count 1x 100 µL

About this product

Recognizes a protein of 36 kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t (11; 14) (q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative) . About 40% of breast carcinomas are positive for Cyclin D1. Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNCB0007-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: B cell CLL/lymphoma 1; B cell leukemia 1; B-cell lymphoma 1 protein; BCL-1 oncogene; CCND1 protein; CCND1/FSTL3 fusion gene; CCND1/IGHG1 fusion gene CCND1/IGLC1 fusion gene; CCND1/PTH fusion gene; G1/S-specific cyclin-D1; Parathyroid adenomatosis 1; PRAD1 oncogene
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: CCND1
Gene ID: 595
NCBI Gene ID: 523852; 667996
UniProt: P24385
Swiss Prot: P24385
Host: Mouse
Species Reactivity: Human, Monkey, Mouse, Rat
Reactivity: Cyclin D1
Immunogen: Human full length recombinant cyclin D1 protein
Target Antigen: Cyclin D1
Clonality: Monoclonal
Clone: DCS-6
Type: Primary
Source: Animal
Origin: Animal
Applications: Flow, intracellular (verified) |IHC, FFPE (verified) |WB (verified)
Field of Research: Cancer, Cell cycle
Positive Control: T47D, ZR75, BT474, SKBR3, MCF-7, MDA-MB-453, HT29, Ramos, Jurkat or A431 cells. Mantle cell lymphoma, breast or bladder carcinomas.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 36 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG2a, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: Biotin

Frequently Asked Questions

What is the catalog number for Cyclin D1 (DCS-6), Biotin conjugate, 0.1mg/mL?

The catalog number for Cyclin D1 (DCS-6), Biotin conjugate, 0.1mg/mL is BNCB0007-100.

What sizes are available for Cyclin D1 (DCS-6), Biotin conjugate, 0.1mg/mL?

Cyclin D1 (DCS-6), Biotin conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is Cyclin D1 (DCS-6), Biotin conjugate, 0.1mg/mL in stock?

Cyclin D1 (DCS-6), Biotin conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Cyclin D1 (DCS-6), Biotin conjugate, 0.1mg/mL?

Cyclin D1 (DCS-6), Biotin conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Cyclin D1 (DCS-6), Biotin conjugate, 0.1mg/mL?

Estimated delivery time for Cyclin D1 (DCS-6), Biotin conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Cyclin D1 (DCS-6), Biotin conjugate, 0.1mg/mL?

The safety data sheet for Cyclin D1 (DCS-6), Biotin conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is Cyclin D1 (DCS-6), Biotin conjugate, 0.1mg/mL used for?

What is the molecular weight of the target protein?

Molecular weight information, where applicable, is listed on the datasheet under target details, useful for confirming the correct band on western blot.

How long will it take to receive this product if it’s custom made?

Lead times depend on the product type: custom polyclonal antibodies typically take 12-14 weeks, monoclonal antibodies 15-17 weeks, made-to-order recombinant proteins 4-8 weeks, and made-to-order recombinant antibodies 6-8 weeks. These are estimates and may shift due to production delays.

What is the recommended dilution for this antibody?

A recommended dilution range for each validated application is provided on the datasheet, but optimal dilution should be titrated for your specific experimental system, sample type, and detection method.