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Product details

Cyclin D1 (DCS-6), CF594 conjugate, 0.1mg/mL

Catalog number BNC940007-500

Price for BNC940007-500

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Size / count 1x 500 µL

About this product

Recognizes a protein of 36 kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t (11; 14) (q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative) . About 40% of breast carcinomas are positive for Cyclin D1. Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number
BNC940007-500
Size / count
1x 500 µL
Dry ice
No
Hazardous
No
Discontinued
No
CAS Number
9007-83-4
Synonyms
B cell CLL/lymphoma 1; B cell leukemia 1; B-cell lymphoma 1 protein; BCL-1 oncogene; CCND1 protein; CCND1/FSTL3 fusion gene; CCND1/IGHG1 fusion gene CCND1/IGLC1 fusion gene; CCND1/PTH fusion gene; G1/S-specific cyclin-D1; Parathyroid adenomatosis 1; PRAD1 oncogene
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
CCND1
Gene ID
595
NCBI Gene ID
523852; 667996
UniProt
P24385
Swiss Prot
P24385
Host
Mouse
Species Reactivity
Human, Monkey, Mouse, Rat
Reactivity
Cyclin D1
Immunogen
Human full length recombinant cyclin D1 protein
Target Antigen
Cyclin D1
Clonality
Monoclonal
Clone
DCS-6
Type
Primary
Source
Animal
Origin
Animal
Applications
Flow, intracellular (verified) |IHC, FFPE (verified) |WB (verified)
Field of Research
Cancer, Cell cycle
Positive Control
T47D, ZR75, BT474, SKBR3, MCF-7, MDA-MB-453, HT29, Ramos, Jurkat or A431 cells. Mantle cell lymphoma, breast or bladder carcinomas.
Stability
2 years
Concentration
0.1 mg/mL
Buffer
PBS, 0.1% BSA, 0.05% azide
Molecular Weight
36 kDa
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Notes
Protect from light
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment
IgG2a, kappa
Species
Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification
0.05% sodium azide (CAS 26628-22-8)
Conjugate
CF594

Frequently Asked Questions

What is the catalog number for Cyclin D1 (DCS-6), CF594 conjugate, 0.1mg/mL?

The catalog number for Cyclin D1 (DCS-6), CF594 conjugate, 0.1mg/mL is BNC940007-500.

What sizes are available for Cyclin D1 (DCS-6), CF594 conjugate, 0.1mg/mL?

Cyclin D1 (DCS-6), CF594 conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is Cyclin D1 (DCS-6), CF594 conjugate, 0.1mg/mL in stock?

Cyclin D1 (DCS-6), CF594 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Cyclin D1 (DCS-6), CF594 conjugate, 0.1mg/mL?

Cyclin D1 (DCS-6), CF594 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Cyclin D1 (DCS-6), CF594 conjugate, 0.1mg/mL?

Estimated delivery time for Cyclin D1 (DCS-6), CF594 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Cyclin D1 (DCS-6), CF594 conjugate, 0.1mg/mL?

The safety data sheet for Cyclin D1 (DCS-6), CF594 conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is Cyclin D1 (DCS-6), CF594 conjugate, 0.1mg/mL used for?

Recognizes a protein of 36 kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t

What is the shelf life of this product?

Shelf life and expiration dates vary by product and are shown on the product listing and label. Products used beyond their expiration date are not eligible for performance-related returns or refunds, so please check the lot number and expiry before use.

What expression system was used for this recombinant protein?

The expression system, such as E. coli, HEK293, or insect cells, is listed on the datasheet under production details, which can affect post-translational modifications relevant to your application.

Can I return this product if I ordered the wrong one?

As a consumer, you have a 14-day right of withdrawal from receipt under EU consumer protection law, submitted via our withdrawal/cancellation request form. Note this applies to unused, undamaged products, and doesn’t override the expiry/storage conditions on performance-based claims.

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