DOG-1 (DG1/447), CF488A conjugate, 0.1mg/mL

Catalog number BNC880447-500

Price for BNC880447-500

Size / count 1x 500 µL

About this product

Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4% vs. 94.7%.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC880447-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: Anoctamin 1; Calcium Activated Chloride Channel; Discovered On Gastrointestinal Stromal Tumors Protein 1; TAOS2; ORAOV2; TMEM16A
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: TMEM16A
Gene ID: 55107
NCBI Gene ID: 503074
UniProt: Q5XXA6
Swiss Prot: Q5XXA6
Host: Mouse
Species Reactivity: Human
Reactivity: DOG-1|TMEM16A
Immunogen: Recombinant human DOG-1 protein
Target Antigen: DOG-1 | TMEM16A
Clonality: Monoclonal
Clone: DG1/447
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Field of Research: Cancer
Positive Control: Gastrointestinal Stromal Tumor (GIST) or testicular germ cell tumor. Melanocytes in the basal layer of the epidermis and mast cells in the dermis of normal skin.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: ~114 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF488A

Frequently Asked Questions

What is the catalog number for DOG-1 (DG1/447), CF488A conjugate, 0.1mg/mL?

The catalog number for DOG-1 (DG1/447), CF488A conjugate, 0.1mg/mL is BNC880447-500.

What sizes are available for DOG-1 (DG1/447), CF488A conjugate, 0.1mg/mL?

DOG-1 (DG1/447), CF488A conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is DOG-1 (DG1/447), CF488A conjugate, 0.1mg/mL in stock?

DOG-1 (DG1/447), CF488A conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures DOG-1 (DG1/447), CF488A conjugate, 0.1mg/mL?

DOG-1 (DG1/447), CF488A conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for DOG-1 (DG1/447), CF488A conjugate, 0.1mg/mL?

Estimated delivery time for DOG-1 (DG1/447), CF488A conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for DOG-1 (DG1/447), CF488A conjugate, 0.1mg/mL?

The safety data sheet for DOG-1 (DG1/447), CF488A conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is DOG-1 (DG1/447), CF488A conjugate, 0.1mg/mL used for?

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.

What temperature does this product ship at?

Shipping temperature is chosen based on the product’s stability needs, ranging from ambient to dry ice, and is indicated on the product page. Any related shipping fee is shown clearly in your quotation.

What is the molecular weight of the target protein?

Molecular weight information, where applicable, is listed on the datasheet under target details, useful for confirming the correct band on western blot.