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Product details

Estrogen Receptor beta 1 (ERb455), 1mg/mL

Catalog number BNUM0455-50

Price for BNUM0455-50

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Size / count 1x 50 µL

About this product

Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER-alpha and ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER-alpha and ER-beta may be regulated by distinct mechanisms even though they share many functional characteristics.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number
BNUM0455-50
Size / count
1x 50 µL
Dry ice
No
Hazardous
No
Discontinued
No
CAS Number
9007-83-4
Synonyms
Erb, ESR BETA, ESR2, ESRB, ESTRB, estrogen nuclear receptor beta variant a, estrogen nuclear receptor beta variant b, estrogen receptor 2 (ER beta), estrogen receptor beta 4
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
ESR2
Gene ID
2100
NCBI Gene ID
660607
UniProt
Q92731
Swiss Prot
Q92731
Host
Mouse
Species Reactivity
Horse, Human, Monkey, Mouse, Pig, Rat, Sheep
Reactivity
Estrogen Receptor Beta 1
Immunogen
C-terminus fragment of recombinant human estrogen receptor beta protein
Target Antigen
Estrogen Receptor Beta 1
Clonality
Monoclonal
Clone
ERb455
Type
Primary
Source
Animal
Origin
Animal
Applications
Flow, intracellular (verified) |IHC, FFPE (verified) |WB (verified)
Field of Research
Cancer, Endocrinology, Nuclear receptors
Positive Control
MCF-7 Cells. Ovarian, Breast, Bladder, Gastric or Salivary carcinoma
Stability
2 years
Concentration
1 mg/mL
Buffer
PBS, no BSA, no azide
Molecular Weight
53-59 kDa
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment
IgG2a
Species
Mus musculus (mouse)
Classification
PBS, no BSA, no sodium azide (CAS 26628-22-8)
Conjugate
Purified, BSA-free

Frequently Asked Questions

What is the catalog number for Estrogen Receptor beta 1 (ERb455), 1mg/mL?

The catalog number for Estrogen Receptor beta 1 (ERb455), 1mg/mL is BNUM0455-50.

What sizes are available for Estrogen Receptor beta 1 (ERb455), 1mg/mL?

Estrogen Receptor beta 1 (ERb455), 1mg/mL is available in the following size(s): 1x 50 µL.

Is Estrogen Receptor beta 1 (ERb455), 1mg/mL in stock?

Estrogen Receptor beta 1 (ERb455), 1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Estrogen Receptor beta 1 (ERb455), 1mg/mL?

Estrogen Receptor beta 1 (ERb455), 1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Estrogen Receptor beta 1 (ERb455), 1mg/mL?

Estimated delivery time for Estrogen Receptor beta 1 (ERb455), 1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Estrogen Receptor beta 1 (ERb455), 1mg/mL?

The safety data sheet for Estrogen Receptor beta 1 (ERb455), 1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is Estrogen Receptor beta 1 (ERb455), 1mg/mL used for?

Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of repro

What should I check when this product first arrives?

Inspect the package immediately for transportation damage, ice loss, leakage, or breakage. Report any issues right away with photos and your order reference; our specialists will determine whether the product is still usable or needs replacing.

Does this cell line or biologic require a Material Transfer Agreement (MTA)?

Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.

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