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Product details

Estrogen Receptor beta 1 (ERb455), CF640R conjugate, 0.1mg/mL

Catalog number BNC400455-100

Price for BNC400455-100

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Size / count 1x 100 µL

About this product

Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER-alpha and ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER-alpha and ER-beta may be regulated by distinct mechanisms even though they share many functional characteristics.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number
BNC400455-100
Size / count
1x 100 µL
Dry ice
No
Hazardous
No
Discontinued
No
CAS Number
9007-83-4
Synonyms
Erb, ESR BETA, ESR2, ESRB, ESTRB, estrogen nuclear receptor beta variant a, estrogen nuclear receptor beta variant b, estrogen receptor 2 (ER beta), estrogen receptor beta 4
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
ESR2
Gene ID
2100
NCBI Gene ID
660607
UniProt
Q92731
Swiss Prot
Q92731
Host
Mouse
Species Reactivity
Horse, Human, Monkey, Mouse, Pig, Rat, Sheep
Reactivity
Estrogen Receptor Beta 1
Immunogen
C-terminus fragment of recombinant human estrogen receptor beta protein
Target Antigen
Estrogen Receptor Beta 1
Clonality
Monoclonal
Clone
ERb455
Type
Primary
Source
Animal
Origin
Animal
Applications
Flow, intracellular (verified) |IHC, FFPE (verified) |WB (verified)
Field of Research
Cancer, Endocrinology, Nuclear receptors
Positive Control
MCF-7 Cells. Ovarian, Breast, Bladder, Gastric or Salivary carcinoma
Stability
2 years
Concentration
0.1 mg/mL
Buffer
PBS, 0.1% BSA, 0.05% azide
Molecular Weight
53-59 kDa
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Notes
Protect from light
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment
IgG2a
Species
Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification
0.05% sodium azide (CAS 26628-22-8)
Conjugate
CF640R

Frequently Asked Questions

What is the catalog number for Estrogen Receptor beta 1 (ERb455), CF640R conjugate, 0.1mg/mL?

The catalog number for Estrogen Receptor beta 1 (ERb455), CF640R conjugate, 0.1mg/mL is BNC400455-100.

What sizes are available for Estrogen Receptor beta 1 (ERb455), CF640R conjugate, 0.1mg/mL?

Estrogen Receptor beta 1 (ERb455), CF640R conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is Estrogen Receptor beta 1 (ERb455), CF640R conjugate, 0.1mg/mL in stock?

Estrogen Receptor beta 1 (ERb455), CF640R conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Estrogen Receptor beta 1 (ERb455), CF640R conjugate, 0.1mg/mL?

Estrogen Receptor beta 1 (ERb455), CF640R conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Estrogen Receptor beta 1 (ERb455), CF640R conjugate, 0.1mg/mL?

Estimated delivery time for Estrogen Receptor beta 1 (ERb455), CF640R conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Estrogen Receptor beta 1 (ERb455), CF640R conjugate, 0.1mg/mL?

The safety data sheet for Estrogen Receptor beta 1 (ERb455), CF640R conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is Estrogen Receptor beta 1 (ERb455), CF640R conjugate, 0.1mg/mL used for?

Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of repro

What is the recommended storage temperature after reconstitution?

Post-reconstitution storage guidance is listed on the datasheet, typically requiring aliquoting and storage at -20°C or -80°C to preserve activity.

Can this product be used in multiplex assays?

Multiplex compatibility depends on the specific product and detection panel. Contact our technical support team with details of your multiplex system for guidance before ordering.

What happens if this product doesn’t perform as expected in my experiment?

Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.

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