Aurora B (Proliferation Marker) (AURKB/1593), CF740 conjugate, 0.1mg/mL

Catalog number BNC741593-100

Price for BNC741593-100

Size / count 1x 100 µL

About this product

This antibody recognizes a protein of 39 kDa, which is identified as Aurora kinase B (or Aurora B) . Aurora B is a serine/threonine protein kinase and component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. It is important for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC741593-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: Aurora kinase B; Aurora B; Aurora-1; AURKB; AIK2; AIM-1; ARK-2; AurB; Aurora and Ipl1 like midbody associated protein 1; Aurora-B; Aurora-related kinase 2; Aurora/IPL1-related kinase 2; IPL1; Protein phosphatase 1 regulatory subunit 48; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase aurora-B; STK1; STK12; STK5
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: AURKB
Gene ID: 9212
NCBI Gene ID: 442658
UniProt: Q96GD4
Swiss Prot: Q96GD4
Host: Mouse
Species Reactivity: Human
Reactivity: Aurora kinase B
Immunogen: Recombinant fragment (around aa 89-251) of human Aurora B protein (exact sequence is proprietary)
Target Antigen: Aurora kinase B
Clonality: Monoclonal
Clone: AURKB/1593
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Field of Research: Cancer, Cell cycle
Positive Control: HeLa cells. Tonsil, Placenta, Hodgkin's Lymphoma or Colon Carcinoma.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% rBSA, 0.05% azide
Molecular Weight: 39 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), Bos taurus (bovine)
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF740

Frequently Asked Questions

What is the catalog number for Aurora B (Proliferation Marker) (AURKB/1593), CF740 conjugate, 0.1mg/mL?

The catalog number for Aurora B (Proliferation Marker) (AURKB/1593), CF740 conjugate, 0.1mg/mL is BNC741593-100.

What sizes are available for Aurora B (Proliferation Marker) (AURKB/1593), CF740 conjugate, 0.1mg/mL?

Aurora B (Proliferation Marker) (AURKB/1593), CF740 conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is Aurora B (Proliferation Marker) (AURKB/1593), CF740 conjugate, 0.1mg/mL in stock?

Aurora B (Proliferation Marker) (AURKB/1593), CF740 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Aurora B (Proliferation Marker) (AURKB/1593), CF740 conjugate, 0.1mg/mL?

Aurora B (Proliferation Marker) (AURKB/1593), CF740 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Aurora B (Proliferation Marker) (AURKB/1593), CF740 conjugate, 0.1mg/mL?

Estimated delivery time for Aurora B (Proliferation Marker) (AURKB/1593), CF740 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Aurora B (Proliferation Marker) (AURKB/1593), CF740 conjugate, 0.1mg/mL?

The safety data sheet for Aurora B (Proliferation Marker) (AURKB/1593), CF740 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd02a6061270361e105f0c/msds/bnc741593-100.pdf.

What is Aurora B (Proliferation Marker) (AURKB/1593), CF740 conjugate, 0.1mg/mL used for?

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.

What is the difference between this product and a similar catalogue number?

Differences typically involve clone, conjugate, host species, or validated applications. Compare the respective datasheets, or contact us with both catalogue numbers for a direct comparison.

Do you offer custom or private-label production of this type of product?

Yes, custom antibody development and private-label production services are available. Contact our sales team to discuss your target, timeline, and quantity requirements.