IDH1 (IDH1/1152), CF488A conjugate, 0.1mg/mL — image 1 of 2

Product details

IDH1 (IDH1/1152), CF488A conjugate, 0.1mg/mL

Catalog number BNC881152-500

Price for BNC881152-500

Size / count 1x 500 µL

About this product

This antibody recognizes a 45 kDa protein, which is identified as isocitrate dehydrogenase (IDH1) . It belongs to the isocitrate and isopropylmalate dehydrogenases family. IDH1 catalyzes the third step of the citric acid cycle, which involves the oxidative decarboxylation of isocitrate, forming alpha-ketoglutarate and CO2 in a two-step reaction. The first step involves the oxidation of isocitrate to the intermediate oxalosuccinate, while the second step involves the production of alpha-ketoglutarate. During this process, either NADH or NADPH is produced along with CO2. Recently, an inactivating mutation of IDH1 has been implicated in glioblastoma. IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC881152-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: Cytosolic NADP-isocitrate dehydrogenase; Epididymis luminal protein 216; Epididymis secretory protein Li 26; HEL-216; HEL-S-26; ICDH; IDCD; IDH1; IDP; IDPC; Isocitrate dehydrogenase 1 (NADP) soluble; NADP dependent isocitrate dehydrogenase peroxisomal; NADP () -specific ICDH; Oxalosuccinate decarboxylase; PICD
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: IDH1
Gene ID: 3417
NCBI Gene ID: 593422
UniProt: O75874
Swiss Prot: O75874
Host: Mouse
Species Reactivity: Human
Reactivity: IDH1
Immunogen: Recombinant fragment (119 Amino acid residues around aa 280-420) of human IDH1 protein
Target Antigen: IDH1
Clonality: Monoclonal
Clone: IDH1/1152
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Field of Research: Cancer, Metabolism
Positive Control: HepG2, HeLa, HT29 or MCF7 cells. Breast, Colon or Prostate Carcinoma.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 45-47 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF488A

Frequently Asked Questions

What is the catalog number for IDH1 (IDH1/1152), CF488A conjugate, 0.1mg/mL?

The catalog number for IDH1 (IDH1/1152), CF488A conjugate, 0.1mg/mL is BNC881152-500.

What sizes are available for IDH1 (IDH1/1152), CF488A conjugate, 0.1mg/mL?

IDH1 (IDH1/1152), CF488A conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is IDH1 (IDH1/1152), CF488A conjugate, 0.1mg/mL in stock?

IDH1 (IDH1/1152), CF488A conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures IDH1 (IDH1/1152), CF488A conjugate, 0.1mg/mL?

IDH1 (IDH1/1152), CF488A conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for IDH1 (IDH1/1152), CF488A conjugate, 0.1mg/mL?

Estimated delivery time for IDH1 (IDH1/1152), CF488A conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for IDH1 (IDH1/1152), CF488A conjugate, 0.1mg/mL?

The safety data sheet for IDH1 (IDH1/1152), CF488A conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is IDH1 (IDH1/1152), CF488A conjugate, 0.1mg/mL used for?

How do I reconstitute this lyophilized product?

Reconstitution instructions, including the recommended diluent and final concentration, are provided on the datasheet. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles.

What is the recommended incubation time for this antibody?

A suggested incubation time is provided in the recommended protocol on the datasheet, but may need adjusting depending on your sample type and detection system.

What should I check when this product first arrives?

Inspect the package immediately for transportation damage, ice loss, leakage, or breakage. Report any issues right away with photos and your order reference; our specialists will determine whether the product is still usable or needs replacing.