Involucrin (SY5), CF405S conjugate, 0.1mg/mL

Catalog number BNC040678-100

Price for BNC040678-100

Size / count 1x 100 µL

About this product

This antibody recognizes a protein of 66 kDa-170 kDa, identified as involucrin. In Western blotting of cultured human keratinocytes, this MAb reacts with a 120 kDa protein. It stains the involucrin in a variety of sizes: 170 kDa in MCF-7 cells, a doublet of ~115 kDa and 150 kDa in gorilla and owl monkey, 66 kDa in dog, and a doublet of 105 kDa in pig. Its epitope maps between codon 421-568 of human involucrin. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea, which lacks a distinct cornified layer. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures, all cells that have left the basal layer express it. Involucrin expression is altered in pathological conditions: in psoriasis and other benign epidermal hyperplasias, involucrin expression begins closer to the basal layer than normal; expression is abnormal in squamous cell carcinomas and premalignant lesions, and is reduced in severe dysplasias of the larynx and cervix.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC040678-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: IVL
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: IVL
Gene ID: 3713
NCBI Gene ID: 516439
UniProt: P07476
Swiss Prot: P07476
Host: Mouse
Species Reactivity: Dog, Gorilla, Human, Monkey, Owl, Pig
Reactivity: Involucrin
Immunogen: Purified involucrin from human keratinocytes
Target Antigen: Involucrin
Clonality: Monoclonal
Clone: SY5
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Field of Research: Cancer
Positive Control: MCF-7 cells. Localized to upper spinous and granular layers in normal skin.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 66-170 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF405S

Frequently Asked Questions

What is the catalog number for Involucrin (SY5), CF405S conjugate, 0.1mg/mL?

The catalog number for Involucrin (SY5), CF405S conjugate, 0.1mg/mL is BNC040678-100.

What sizes are available for Involucrin (SY5), CF405S conjugate, 0.1mg/mL?

Involucrin (SY5), CF405S conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is Involucrin (SY5), CF405S conjugate, 0.1mg/mL in stock?

Involucrin (SY5), CF405S conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Involucrin (SY5), CF405S conjugate, 0.1mg/mL?

Involucrin (SY5), CF405S conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Involucrin (SY5), CF405S conjugate, 0.1mg/mL?

Estimated delivery time for Involucrin (SY5), CF405S conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Involucrin (SY5), CF405S conjugate, 0.1mg/mL?

The safety data sheet for Involucrin (SY5), CF405S conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is Involucrin (SY5), CF405S conjugate, 0.1mg/mL used for?

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.

What is the difference between this product and a similar catalogue number?

Differences typically involve clone, conjugate, host species, or validated applications. Compare the respective datasheets, or contact us with both catalogue numbers for a direct comparison.

Do you offer custom or private-label production of this type of product?

Yes, custom antibody development and private-label production services are available. Contact our sales team to discuss your target, timeline, and quantity requirements.