Ku-Holo (p70;83) (KU729), 0.2mg/mL — image 1 of 4

Product details

Ku-Holo (p70;83) (KU729), 0.2mg/mL

Catalog number BNUB0729-500

Price for BNUB0729-500

Size / count 1x 500 µL

About this product

Recognizes a dimer of two proteins of 70 kDa and ~80 kDa, identified as two subunits of Ku. This MAb recognizes a conformational epitope of p70/p80 dimer, which is destroyed during Western blotting. The p70/p80 dimer is important for function of a 460 kDa DNA-dependent protein kinase. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNUB0729-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: Ku (p70) : 70kDa subunit of Ku antigen; ATP dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70kDa subunit; CTC box-binding factor 75kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; G22P1; Ku autoantigen, 70kDa; Ku70; Kup70; Lupus Ku autoantigen protein p70; ML8; Thyroid autoantigen 70kD (Ku antigen) ; Thyroid-lupus autoantigen (TLAA) ; X-ray repair cross-complementing protein 6 (XRCC6) Ku (p80) : 86kDa subunit of Ku antigen; ATP dependent DNA helicase 2 subunit 2; ATP dependent DNA helicase II 86Kd subunit; ATP-dependent DNA helicase II 80kDa subunit; CTC box-binding factor 85kDa subunit; CTC85; CTCBF; DNA repair protein XRCC5; KARP1; Ku autoantigen 80kDa; Ku80; Ku86 autoantigen related protein 1; KUB2; Lupus Ku autoantigen protein p86; Nuclear factor IV (NFIV) ; Thyroid-lupus autoantigen (TLAA) ; X-ray repair cross-complementing protein 5 (XRCC5)
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: XRCC6
Gene ID: 2547 (p70); 7520 (p80)
NCBI Gene ID: 292493 (p70); 388739 (p80)
UniProt: P12956 (p70); P13010 (p80)
Swiss Prot: P12956 (p70) ; P13010 (p80)
Host: Mouse
Species Reactivity: Human, Non-human primates
Reactivity: Ku-Holo
Immunogen: Nuclear extract of human HL-60 cells
Target Antigen: Ku-Holo
Clonality: Monoclonal
Clone: KU729
Type: Primary
Source: Animal
Origin: Animal
Applications: Flow, intracellular (verified) |IF (verified)
Field of Research: Apoptosis, Cell cycle, Signal transduction
Positive Control: Human cancer K562, HL-60, HEp-2 or HeLa cells
Stability: 2 years
Concentration: 0.2 mg/mL
Buffer: PBS, 0.05% BSA, 0.05% azide
Molecular Weight: 70 kDa & 80 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)
Conjugate: Purified, with BSA

Frequently Asked Questions

What is the catalog number for Ku-Holo (p70;83) (KU729), 0.2mg/mL?

The catalog number for Ku-Holo (p70;83) (KU729), 0.2mg/mL is BNUB0729-500.

What sizes are available for Ku-Holo (p70;83) (KU729), 0.2mg/mL?

Ku-Holo (p70;83) (KU729), 0.2mg/mL is available in the following size(s): 1x 500 µL.

Is Ku-Holo (p70;83) (KU729), 0.2mg/mL in stock?

Ku-Holo (p70;83) (KU729), 0.2mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Ku-Holo (p70;83) (KU729), 0.2mg/mL?

Ku-Holo (p70;83) (KU729), 0.2mg/mL is manufactured by Biotium.

What is the estimated delivery time for Ku-Holo (p70;83) (KU729), 0.2mg/mL?

Estimated delivery time for Ku-Holo (p70;83) (KU729), 0.2mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Ku-Holo (p70;83) (KU729), 0.2mg/mL?

The safety data sheet for Ku-Holo (p70;83) (KU729), 0.2mg/mL is available here: https://cdn.gentaur.com/products/37/68dd0299061270361e1011f2/msds/bnub0729-500.pdf.

What is Ku-Holo (p70;83) (KU729), 0.2mg/mL used for?

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.

What is the difference between this product and a similar catalogue number?

Differences typically involve clone, conjugate, host species, or validated applications. Compare the respective datasheets, or contact us with both catalogue numbers for a direct comparison.