Major Vault Protein (MVP) (1032), Biotin conjugate, 0.1mg/mL

About this product

Recognizes a protein of 104 kDa-110 kDa, characterized as major vault protein (MVP) . Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNCB0225-500

Size / count

1x 500 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

Lung resistance-related protein (LRP) ; Major Vault Protein; MVP; VAULT1

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

MVP

Gene ID

9961

NCBI Gene ID

632177

UniProt

Q14764

Swiss Prot

Q14764

Host

Mouse

Species Reactivity

Human

Reactivity

Major Vault Protein

Immunogen

Proteins precipitated from human breast cancer MCF-7 cells

Target Antigen

Major Vault Protein

Clonality

Monoclonal

Clone

1032

Type

Primary

Source

Animal

Origin

Animal

Applications

IHC, FFPE (verified) |WB (published)

Field of Research

Cancer, Endocrinology

Positive Control

MCF-7/HeLa, breast tumors

Stability

2 years

Concentration

0.1 mg/mL

Buffer

PBS, 0.1% BSA, 0.05% azide

Molecular Weight

104-110 kDa

References & Citations

Note: References for this clone sold by other suppliers may be listed for expected applications. Mol Cell Proteomics (2013) 12(7): 2006-2020. (WB)

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG1, kappa

Species

Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

Classification

0.05% sodium azide (CAS 26628-22-8)

Conjugate

Biotin