MUC18 / Mucin 18 / CD146 (OJ79c), CF488A conjugate, 0.1mg/mL

About this product

The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2 -independent cell adhesion molecule. Mel-CAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. Mel-CAM is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNC880676-500

Size / count

1x 500 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

Cell Surface Glycoprotein MUC18; Cell Surface Glycoprotein P1H12; Gicerin; Melanoma Adhesion Molecule (MCAM) ; Melanoma Associated Glycoprotein MUC18; Melanoma Cell Adhesion Molecule; Melanoma-associated Antigen A32; Mel-CAM; S-endo 1 Endothelial-associated Antigen; Sendo1

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

MCAM

Gene ID

4162

NCBI Gene ID

599039

UniProt

P43121

Swiss Prot

P43121

Host

Mouse

Species Reactivity

Human

Reactivity

CD146|MCAM|MUC18|Mucin 18

Immunogen

Recombinant human MUC18 protein

Target Antigen

CD146 | MCAM | MUC18 | Mucin 18

Clonality

Monoclonal

Clone

OJ79c

Type

Primary

Source

Animal

Origin

Animal

Applications

Flow, surface (published) |IF (published) |ELISA (published)

Field of Research

Cancer, Mucins

Positive Control

A-375, HUV-EC or HeLa Cells. Tonsil or Melanoma.

Stability

2 years

Concentration

0.1 mg/mL

Buffer

PBS, 0.1% BSA, 0.05% azide

Molecular Weight

130 kDa

References & Citations

Note: References for this clone sold by other suppliers may be listed for expected applications. Microvascular Res (2009)78(3): 325-331. (ELISA) Stem Cells (2008) 26: 2408-2418. (Flow) Stem Cells and Development (2017) 26(13): 964. (IF)

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Notes

Protect from light

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG1, kappa

Species

Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

Classification

0.05% sodium azide (CAS 26628-22-8)

Conjugate

CF488A