MUC2 (CCP58), CF640R conjugate, 0.1mg/mL

About this product

Recognizes a single glycoprotein of 520 kDa, identified as mucin 2 (MUC2) . This MAb shows no cross-reaction with human milk fat globule membranes, MUC1, or MUC3. Its epitope has been defined as GTQTP (GlyThrGlnThrPro) . Mucins are high molecular weight glycoproteins, which constitute the major component of the mucus layer that protects the gastric epithelium. MUC2 is specifically expressed in goblet cells of the small intestine & colon; in about 65% of colonic carcinomas and about 40% of gastric carcinomas. MUC2 is rarely expressed outside of the GI tract with the exceptions of mucinous carcinoma of breast and clear cell-type carcinomas of the ovary. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNC400032-500

Size / count

1x 500 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

Mucin-2, Intestinal mucin-2, Mucin like protein, (MLP), SMUC

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

MUC2

Gene ID

4583

NCBI Gene ID

315

UniProt

Q02817

Swiss Prot

Q02817

Host

Mouse

Species Reactivity

Human

Reactivity

MUC2|Mucin 2

Immunogen

A synthetic peptide of 29 amino acids, KYPTTTPISTTTMVTPTPTPTGTQTPTTT from MUC2 protein, coupled to KLH.

Target Antigen

MUC2 | Mucin 2

Clonality

Monoclonal

Clone

CCP58

Type

Primary

Source

Animal

Origin

Animal

Applications

IF (published) |ELISA (published) |IHC, FFPE (verified) |WB (published)

Field of Research

Cancer, Mucins

Positive Control

LS174T cells or small intestine.

Stability

2 years

Concentration

0.1 mg/mL

Buffer

PBS, 0.1% BSA, 0.05% azide

Molecular Weight

520 kDa

References & Citations

Note: References for this clone sold by other suppliers may be listed for expected applications. Int J Cancer (1997)73: 795-801. (ELISA) Gastroenterol (2002) 123(3):817-826. (WB) Gastroenterol (2002) 123(4): 1052-1060. (IHC, FFPE) SEPTEMBER 01, 2002Chem Senses (2019) 44(7): 511-521. (IF, frozen tissue sections)

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Notes

Protect from light

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG1, kappa

Species

Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

Classification

0.05% sodium azide (CAS 26628-22-8)

Conjugate

CF640R