P21 / WAF1 (CIP1/823 + DCS-60.2), Biotin conjugate, 0.1mg/mL

Catalog number BNCB1135-100

Price for BNCB1135-100

Size / count 1x 100 µL

About this product

This MAb recognizes a 21 kDa protein, identified as the p21WAF1 tumor suppressor protein. This MAb is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21WAF1 is a specific inhibitor of cdk's and a tumor suppressor involved in the pathogenesis of a variety of malignancies. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. Its expression is induced by the wild type, but not mutant, p53 suppressor protein. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma) .Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNCB1135-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: Activating Fragment 1; CAP20; CDK-interacting protein 1; CDKI; CDKN1; CDKN1A; CIP1; Cyclin-dependent kinase inhibitor 1A (p21; Cip1) ; DNA Synthesis Inhibitor; MDA6; Melanoma Differentiation Associated Protein 6; p21Cip1/Waf1; PIC1; SDI1; SLC12A9; Wild type p53 activated fragment 1 (WAF1)
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: CDKN1A
Gene ID: 1026
NCBI Gene ID: 370771
UniProt: P38936
Swiss Prot: P38936
Host: Mouse
Species Reactivity: Human
Reactivity: P21|WAF1
Immunogen: Recombinant full-length human CDKN1A protein (CIP1/823) ; Human recombinant p21 protein (DCS-60.2)
Target Antigen: p21 | WAF1
Clonality: Monoclonal
Clone: CIP1/823 DCS-60.2
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified) |WB (verified)
Field of Research: Cell cycle, Tumor suppressors
Positive Control: HeLa Cells. Skin, colon, or breast carcinoma.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 21 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG' s
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: Biotin

Frequently Asked Questions

What is the catalog number for P21 / WAF1 (CIP1/823 + DCS-60.2), Biotin conjugate, 0.1mg/mL?

The catalog number for P21 / WAF1 (CIP1/823 + DCS-60.2), Biotin conjugate, 0.1mg/mL is BNCB1135-100.

What sizes are available for P21 / WAF1 (CIP1/823 + DCS-60.2), Biotin conjugate, 0.1mg/mL?

P21 / WAF1 (CIP1/823 + DCS-60.2), Biotin conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is P21 / WAF1 (CIP1/823 + DCS-60.2), Biotin conjugate, 0.1mg/mL in stock?

P21 / WAF1 (CIP1/823 + DCS-60.2), Biotin conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures P21 / WAF1 (CIP1/823 + DCS-60.2), Biotin conjugate, 0.1mg/mL?

P21 / WAF1 (CIP1/823 + DCS-60.2), Biotin conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for P21 / WAF1 (CIP1/823 + DCS-60.2), Biotin conjugate, 0.1mg/mL?

Estimated delivery time for P21 / WAF1 (CIP1/823 + DCS-60.2), Biotin conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for P21 / WAF1 (CIP1/823 + DCS-60.2), Biotin conjugate, 0.1mg/mL?

The safety data sheet for P21 / WAF1 (CIP1/823 + DCS-60.2), Biotin conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is P21 / WAF1 (CIP1/823 + DCS-60.2), Biotin conjugate, 0.1mg/mL used for?

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.

Can I get a trial-size or discounted first order of this product?

We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.