P27 / KIP1 (SX53G8), CF568 conjugate, 0.1mg/mL — image 1 of 4

Product details

P27 / KIP1 (SX53G8), CF568 conjugate, 0.1mg/mL

Catalog number BNC680669-500

Price for BNC680669-500

Size / count 1x 500 µL

About this product

This MAb recognizes a 27 kDa protein, identified as the p27Kip1, a cell cycle regulatory mitotic inhibitor. It is highly specific and shows no cross-reaction with other related mitotic inhibitors. In Western blotting of cell lysates from 7 human breast cancer cell lines (ZR75-1, ZR75-30, MCF-7, MDAMB453, T47D, CAL51, 734B), the antibody labels a single band corresponding to p27Kip1. It functions as a negative regulator of G1 progression and has been proposed to function as a possible mediator of TGF-betanduced G1 arrest. p27Kip1 is a candidate tumor suppressor gene. Reportedly, low p27 expression has been associated with unfavorable prognosis in renal cell carcinoma, colon carcinoma, breast carcinomas, non-small-cell lung carcinoma, hepatocellular carcinoma, multiple myeloma, and lymph node metastases in papillary carcinoma of the thyroid, as well as a more aggressive phenotype in carcinoma of the cervix.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC680669-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: CDKN1B, CDKN4, Cyclin Dependent Kinase Inhibitor 1B, Cyclin-dependent kinase inhibitor p27 Kip1, KIP1, MEN1B, MEN4
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: CDKN1B
Gene ID: 1027
NCBI Gene ID: 238990
UniProt: P46527
Swiss Prot: P46527
Host: Mouse
Species Reactivity: Human, Monkey, Mouse, Rat
Reactivity: KIP1|p27
Immunogen: Purified GST-p27 fusion protein of human origin
Target Antigen: KIP1 | p27
Clonality: Monoclonal
Clone: SX53G8
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE|Flow, intracellular (verified) |IF (verified) |IP (published) |WB (published)
Field of Research: Cell cycle, Tumor suppressors
Positive Control: ZR75, T47D, SK-BR-3, MDA-MB-231, HeLa or MCF7 cells. Tonsil, Breast, Cervical or Colon Carcinoma.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 25-26 kDa
References & Citations: Note: References for this clone sold by other suppliers may be listed for expected applications._x000D_ 1. PNAS USA (1997) 94:6380-6385. (western; immunoprecipitation; IHC, FFPE)_x000D_ 2. Blood (2005) 105(9): 3691. (western)_x000D_ 3. Anticancer Res (2017) 37: 2407-2415. (IHC, FFPE; IF, western)_x000D_
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF568

Frequently Asked Questions

What is the catalog number for P27 / KIP1 (SX53G8), CF568 conjugate, 0.1mg/mL?

The catalog number for P27 / KIP1 (SX53G8), CF568 conjugate, 0.1mg/mL is BNC680669-500.

What sizes are available for P27 / KIP1 (SX53G8), CF568 conjugate, 0.1mg/mL?

P27 / KIP1 (SX53G8), CF568 conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is P27 / KIP1 (SX53G8), CF568 conjugate, 0.1mg/mL in stock?

P27 / KIP1 (SX53G8), CF568 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures P27 / KIP1 (SX53G8), CF568 conjugate, 0.1mg/mL?

P27 / KIP1 (SX53G8), CF568 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for P27 / KIP1 (SX53G8), CF568 conjugate, 0.1mg/mL?

Estimated delivery time for P27 / KIP1 (SX53G8), CF568 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for P27 / KIP1 (SX53G8), CF568 conjugate, 0.1mg/mL?

The safety data sheet for P27 / KIP1 (SX53G8), CF568 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd02a4061270361e105349/msds/bnc680669-500.pdf.

What is P27 / KIP1 (SX53G8), CF568 conjugate, 0.1mg/mL used for?

Is this product species cross-reactive?

Cross-reactivity data, based on available testing, is listed under the reactivity section of the datasheet. Contact us if you need reactivity confirmed for a species not listed.

Is there an additional fee for hazardous or dry ice shipping of this product?

Yes, if this product requires dry ice or is classed as hazardous for transport, the additional fee will be explicitly shown in your quotation before you confirm the order, so there are no surprise charges later.

How many freeze-thaw cycles can this product tolerate?

We recommend aliquoting the product upon receipt to avoid repeated freeze-thaw cycles, which can reduce activity and stability. This is your responsibility once the product has been delivered.