P53 (DO-7), CF405S conjugate, 0.1mg/mL

Catalog number BNC040513-500

Price for BNC040513-500

Size / count 1x 500 µL

About this product

Recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53. Its epitope maps within the N-terminus (aa 37-45) of p53. Monoclonal antibody PAb1801 does not block the binding of DO-7 MAb to p53 in an ELISA test. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC040513-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: Antigen NY-CO-13, BCC7, Cellular Tumor Antigen p53, LFS1, TP53, Transformation Related Protein 53 (TRP53), Tumor Protein p53, Tumor Suppressor p53
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: TP53
Gene ID: 7157
NCBI Gene ID: 654481
UniProt: P04637
Swiss Prot: P04637
Host: Mouse
Species Reactivity: Cow, Human, Monkey
Reactivity: P53 Tumor Suppressor Protein
Immunogen: Recombinant human wild type p53 protein expressed in E. coli.
Target Antigen: p53 Tumor Suppressor Protein
Clonality: Monoclonal
Clone: DO-7
Type: Primary
Source: Animal
Origin: Animal
Field of Research: Apoptosis, Tumor suppressors
Positive Control: MDA-MB-231 Cells. Breast or Colon carcinoma
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 53 kDa
References & Citations: Vojtesek B et al. 1992. J. Immunol. Methods. 151(1-2): 237-44. | Stephen CW et al. 1995. J Mol. Biol. 248(1): 58-78. |
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG2b, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF405S

Frequently Asked Questions

What is the catalog number for P53 (DO-7), CF405S conjugate, 0.1mg/mL?

The catalog number for P53 (DO-7), CF405S conjugate, 0.1mg/mL is BNC040513-500.

What sizes are available for P53 (DO-7), CF405S conjugate, 0.1mg/mL?

P53 (DO-7), CF405S conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is P53 (DO-7), CF405S conjugate, 0.1mg/mL in stock?

P53 (DO-7), CF405S conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures P53 (DO-7), CF405S conjugate, 0.1mg/mL?

P53 (DO-7), CF405S conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for P53 (DO-7), CF405S conjugate, 0.1mg/mL?

Estimated delivery time for P53 (DO-7), CF405S conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for P53 (DO-7), CF405S conjugate, 0.1mg/mL?

The safety data sheet for P53 (DO-7), CF405S conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is P53 (DO-7), CF405S conjugate, 0.1mg/mL used for?

Do you offer bulk or custom quantities of this product?

Yes. Ordering two or more units, or combining this with other products, usually qualifies for a discount depending on quantity. Contact our sales team with your required volume for a custom quote.

Do you provide a Certificate of Analysis (CoA) for this product?

A Certificate of Analysis is available for most products upon request. Contact our support team with the lot number to obtain the relevant CoA.

Is this product suitable for live cell imaging?

Suitability for live cell imaging depends on the specific reagent and conjugate used. Check the datasheet for imaging-specific validation, or contact us for guidance.