P53 (DO-7), CF405S conjugate, 0.1mg/mL

Catalog number BNC040513-100

Price for BNC040513-100

Size / count 1x 100 µL

About this product

Recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53. Its epitope maps within the N-terminus (aa 37-45) of p53. Monoclonal antibody PAb1801 does not block the binding of DO-7 MAb to p53 in an ELISA test. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC040513-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: Antigen NY-CO-13, BCC7, Cellular Tumor Antigen p53, LFS1, TP53, Transformation Related Protein 53 (TRP53), Tumor Protein p53, Tumor Suppressor p53
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: TP53
Gene ID: 7157
NCBI Gene ID: 654481
UniProt: P04637
Swiss Prot: P04637
Host: Mouse
Species Reactivity: Cow, Human, Monkey
Reactivity: P53 Tumor Suppressor Protein
Immunogen: Recombinant human wild type p53 protein expressed in E. coli.
Target Antigen: p53 Tumor Suppressor Protein
Clonality: Monoclonal
Clone: DO-7
Type: Primary
Source: Animal
Origin: Animal
Field of Research: Apoptosis, Tumor suppressors
Positive Control: MDA-MB-231 Cells. Breast or Colon carcinoma
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 53 kDa
References & Citations: Vojtesek B et al. 1992. J. Immunol. Methods. 151(1-2): 237-44. | Stephen CW et al. 1995. J Mol. Biol. 248(1): 58-78. |
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG2b, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF405S

Frequently Asked Questions

What is the catalog number for P53 (DO-7), CF405S conjugate, 0.1mg/mL?

The catalog number for P53 (DO-7), CF405S conjugate, 0.1mg/mL is BNC040513-100.

What sizes are available for P53 (DO-7), CF405S conjugate, 0.1mg/mL?

P53 (DO-7), CF405S conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is P53 (DO-7), CF405S conjugate, 0.1mg/mL in stock?

P53 (DO-7), CF405S conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures P53 (DO-7), CF405S conjugate, 0.1mg/mL?

P53 (DO-7), CF405S conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for P53 (DO-7), CF405S conjugate, 0.1mg/mL?

Estimated delivery time for P53 (DO-7), CF405S conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for P53 (DO-7), CF405S conjugate, 0.1mg/mL?

The safety data sheet for P53 (DO-7), CF405S conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is P53 (DO-7), CF405S conjugate, 0.1mg/mL used for?

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.

What is the difference between this product and a similar catalogue number?

Differences typically involve clone, conjugate, host species, or validated applications. Compare the respective datasheets, or contact us with both catalogue numbers for a direct comparison.

Do you offer custom or private-label production of this type of product?

Yes, custom antibody development and private-label production services are available. Contact our sales team to discuss your target, timeline, and quantity requirements.