P57 / KIP2 (KP10 + KIP2/880), CF647 conjugate, 0.1mg/mL

Catalog number BNC471015-100

Price for BNC471015-100

Size / count 1x 100 µL

About this product

Recognizes a protein of 57 kDa, identified as p57Kip2. It shows no cross-reaction with p27Kip1. p57Kip2 is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. Anti-p57 has been used as an aide in identification of complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts and stromal cells) from partial hydatidiform mole (PHM) in which both cytotrophoblasts and stromal cells stain. The histological differentiation of complete mole, partial mole, and hydropic spontaneous abortion is problematic. Most complete hydatidiform moles are diploid, whereas most partial moles are triploid. Ploidy studies will identify partial moles, but will not differentiate complete moles from non-molar gestations. Complete moles carry a high risk of persistent disease and choriocarcinoma, while partial moles have a very low risk. In normal placenta, many cytotrophoblast nuclei and stromal cells are labeled with this antibody. Similar findings apply to PHM and hydropic abortus tissues. Intervillous trophoblastic islands (IVTIs) demonstrate nuclear labeling in all three entities and serve as an internal control.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC471015-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: Beckwith Wiedemann syndrome (WBS) ; BWCR; Cyclin dependent kinase inhibitor 1C (CDKN1C) ; Cyclin dependent kinase inhibitor p57; KIP2; p57; p57Kip2
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: CDKN1C
Gene ID: 1028
NCBI Gene ID: 106070
UniProt: P49918
Swiss Prot: P49918
Host: Mouse
Species Reactivity: Human, Mouse
Reactivity: KIP2|p57
Immunogen: Recombinant human p57Kip2 protein
Target Antigen: KIP2 | p57
Clonality: Monoclonal
Clone: KP10 KIP2/880
Type: Primary
Source: Animal
Origin: Animal
Field of Research: Cell cycle, Tumor suppressors
Positive Control: LS174T, Raji, HT29, SK-BR3 cells. Colon or Prostate carcinomas.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 57 kDa
References & Citations: Lee, M.-H., et al. 1995. Cloning of p57, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. Genes Dev. 9: 639-649
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG' s
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF647

Frequently Asked Questions

What is the catalog number for P57 / KIP2 (KP10 + KIP2/880), CF647 conjugate, 0.1mg/mL?

The catalog number for P57 / KIP2 (KP10 + KIP2/880), CF647 conjugate, 0.1mg/mL is BNC471015-100.

What sizes are available for P57 / KIP2 (KP10 + KIP2/880), CF647 conjugate, 0.1mg/mL?

P57 / KIP2 (KP10 + KIP2/880), CF647 conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is P57 / KIP2 (KP10 + KIP2/880), CF647 conjugate, 0.1mg/mL in stock?

P57 / KIP2 (KP10 + KIP2/880), CF647 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures P57 / KIP2 (KP10 + KIP2/880), CF647 conjugate, 0.1mg/mL?

P57 / KIP2 (KP10 + KIP2/880), CF647 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for P57 / KIP2 (KP10 + KIP2/880), CF647 conjugate, 0.1mg/mL?

Estimated delivery time for P57 / KIP2 (KP10 + KIP2/880), CF647 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for P57 / KIP2 (KP10 + KIP2/880), CF647 conjugate, 0.1mg/mL?

The safety data sheet for P57 / KIP2 (KP10 + KIP2/880), CF647 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd02a6061270361e105fac/msds/bnc471015-100.pdf.

What is P57 / KIP2 (KP10 + KIP2/880), CF647 conjugate, 0.1mg/mL used for?

Do you offer bulk or custom quantities of this product?

Yes. Ordering two or more units, or combining this with other products, usually qualifies for a discount depending on quantity. Contact our sales team with your required volume for a custom quote.

Do you provide a Certificate of Analysis (CoA) for this product?

A Certificate of Analysis is available for most products upon request. Contact our support team with the lot number to obtain the relevant CoA.

Is this product suitable for live cell imaging?

Suitability for live cell imaging depends on the specific reagent and conjugate used. Check the datasheet for imaging-specific validation, or contact us for guidance.