SOX10 (SOX10/1074), CF405S conjugate, 0.1mg/mL — image 1 of 2

Product details

SOX10 (SOX10/1074), CF405S conjugate, 0.1mg/mL

Catalog number BNC041017-100

Price for BNC041017-100

Size / count 1x 100 µL

About this product

Recognizes a protein of ~55 kDa, identified as SOX10. This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC041017-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: DOM; PCWH; SOX10; SRY (sex determining region Y) box 10; SRY box containing gene 10; SRY related HMG box gene 10; Waardenburg syndrome type 2E (WS2E) ; WS4; Waardenburg syndrome type 4C (WS4C)
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: SOX10
Gene ID: 6663
NCBI Gene ID: 376984
UniProt: P56693
Swiss Prot: P56693
Host: Mouse
Species Reactivity: Human
Reactivity: SOX10
Immunogen: Recombinant fragment (aa 115-269) of human SOX10 protein with hexa-histidine tag
Target Antigen: SOX10
Clonality: Monoclonal
Clone: SOX10/1074
Type: Primary
Source: Animal
Origin: Animal
Field of Research: Cancer, Developmental biology, Transcription factors
Positive Control: HepG2 cells. Melanomas, breast carcinomas, gliomas.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 49-58 kDa
References & Citations: Mohamed A, et al. SOX10 Expression in malignant melanoma, carcinoma, and normal tissues. Appl Immunohistochem Mol Morphol. 2013; 21(6):506-10.?
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG2b, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF405S

Frequently Asked Questions

What is the catalog number for SOX10 (SOX10/1074), CF405S conjugate, 0.1mg/mL?

The catalog number for SOX10 (SOX10/1074), CF405S conjugate, 0.1mg/mL is BNC041017-100.

What sizes are available for SOX10 (SOX10/1074), CF405S conjugate, 0.1mg/mL?

SOX10 (SOX10/1074), CF405S conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is SOX10 (SOX10/1074), CF405S conjugate, 0.1mg/mL in stock?

SOX10 (SOX10/1074), CF405S conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures SOX10 (SOX10/1074), CF405S conjugate, 0.1mg/mL?

SOX10 (SOX10/1074), CF405S conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for SOX10 (SOX10/1074), CF405S conjugate, 0.1mg/mL?

Estimated delivery time for SOX10 (SOX10/1074), CF405S conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for SOX10 (SOX10/1074), CF405S conjugate, 0.1mg/mL?

The safety data sheet for SOX10 (SOX10/1074), CF405S conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is SOX10 (SOX10/1074), CF405S conjugate, 0.1mg/mL used for?

Is this product tested for endotoxin levels?

Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.