SOX10 (SOX10/991), CF640R conjugate, 0.1mg/mL — image 1 of 5

Product details

SOX10 (SOX10/991), CF640R conjugate, 0.1mg/mL

Catalog number BNC400991-100

Price for BNC400991-100

Size / count 1x 100 µL

About this product

Recognizes a protein of ~55 kDa, identified as SOX10. This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC400991-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: DOM; PCWH; SOX10; SRY (sex determining region Y) box 10; SRY box containing gene 10; SRY related HMG box gene 10; Waardenburg syndrome type 2E (WS2E) ; WS4; Waardenburg syndrome type 4C (WS4C)
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: SOX10
Gene ID: 6663
NCBI Gene ID: 376984
UniProt: P56693
Swiss Prot: P56693
Host: Mouse
Species Reactivity: Human
Reactivity: SOX10
Immunogen: Recombinant fragment (aa 115-269) of human SOX10 protein with hexa-histidine tag
Target Antigen: SOX10
Clonality: Monoclonal
Clone: SOX10/991
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified) |WB (verified)
Field of Research: Cancer, Developmental biology, Transcription factors
Positive Control: HepG2 cells. Melanomas, breast carcinomas, gliomas.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 49-58 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG2b, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF640R

Frequently Asked Questions

What is the catalog number for SOX10 (SOX10/991), CF640R conjugate, 0.1mg/mL?

The catalog number for SOX10 (SOX10/991), CF640R conjugate, 0.1mg/mL is BNC400991-100.

What sizes are available for SOX10 (SOX10/991), CF640R conjugate, 0.1mg/mL?

SOX10 (SOX10/991), CF640R conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is SOX10 (SOX10/991), CF640R conjugate, 0.1mg/mL in stock?

SOX10 (SOX10/991), CF640R conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures SOX10 (SOX10/991), CF640R conjugate, 0.1mg/mL?

SOX10 (SOX10/991), CF640R conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for SOX10 (SOX10/991), CF640R conjugate, 0.1mg/mL?

Estimated delivery time for SOX10 (SOX10/991), CF640R conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for SOX10 (SOX10/991), CF640R conjugate, 0.1mg/mL?

The safety data sheet for SOX10 (SOX10/991), CF640R conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd029d061270361e10281b/msds/bnc400991-100.pdf.

What is SOX10 (SOX10/991), CF640R conjugate, 0.1mg/mL used for?

What is the molecular weight of the target protein?

Molecular weight information, where applicable, is listed on the datasheet under target details, useful for confirming the correct band on western blot.

How long will it take to receive this product if it’s custom made?

Lead times depend on the product type: custom polyclonal antibodies typically take 12-14 weeks, monoclonal antibodies 15-17 weeks, made-to-order recombinant proteins 4-8 weeks, and made-to-order recombinant antibodies 6-8 weeks. These are estimates and may shift due to production delays.

What is the recommended dilution for this antibody?

A recommended dilution range for each validated application is provided on the datasheet, but optimal dilution should be titrated for your specific experimental system, sample type, and detection method.