TGF-beta (1D11.16.8), CF647 conjugate, 0.1mg/mL

About this product

This MAb recognizes TGF beta 1, 2 and 3. Three TGF-betas have been identified in mammals. TGF-beta1, TGF-beta2 and TGF-beta3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGF-beta requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGF-beta3 protein has approximately 80% identity to the mature region of both TGF-beta1 and TGF-beta2. However, the NH2 terminals or precursor regions of their molecules share only 27% sequence identity. TGF-beta's inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNC470977-100

Size / count

1x 100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

GP40; Leu9; p41; T-cell leukemia antigen; T-cell surface antigen Leu-9; Tp40; TP41

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

TGFB1

Gene ID

7040 (beta1), 7042 (beta2) & 7043 (beta3)

NCBI Gene ID

645227

UniProt

P01137 (beta1), P10600 (beta2); P61812 (beta3)

Swiss Prot

P01137 (beta1), P10600 (beta2) & P61812 (beta3)

Host

Mouse

Species Reactivity

Cow, Dog, Hamster, Human, Monkey, Mouse, Rat

Reactivity

TGF-Beta

Immunogen

Bovine TGF-beta2 protein

Target Antigen

TGF-Beta

Clonality

Monoclonal

Clone

1D11.16.8

Type

Primary

Source

Animal

Origin

Animal

Applications

Functional studies (published) |IHC, FFPE (published)

Field of Research

Signal transduction

Positive Control

Salivary gland carcinoma

Stability

2 years

Concentration

0.1 mg/mL

Buffer

PBS, 0.1% BSA, 0.05% azide

Molecular Weight

~13 kDa

References & Citations

Note: References for this clone sold by other suppliers may be listed for expected applications. Biol Reproduct (1992) 46: 561-572. (IHC, FFPE) PLOS ONE 10(7): e0132786. (functional studies)

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Notes

Protect from light

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG1, kappa

Species

Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

Classification

0.05% sodium azide (CAS 26628-22-8)

Conjugate

CF647