Thymidylate Synthase (TS106 + TMS715), CF640R conjugate, 0.1mg/mL

Catalog number BNC400716-500

Price for BNC400716-500

Size / count 1x 500 µL

About this product

This antibody recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45) . TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC400716-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: DTMP synthase, TMS, TS, TSase, TYMS protein, Tyms thymidylate synthetase
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: TYMS
Gene ID: 7298
NCBI Gene ID: 369762
UniProt: P04818
Swiss Prot: P04818
Host: Mouse
Species Reactivity: Human
Reactivity: Thymidylate Synthase
Immunogen: Recombinant human thymidylate synthase (TS106 & TMS715)
Target Antigen: Thymidylate Synthase
Clonality: Monoclonal
Clone: TS106 TMS715
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Field of Research: Cancer, Metabolism
Positive Control: 5-FU-resistant colon carcinoma cell lines (NCI H630R10, NCI H630R1); 5-FU-resistant breast cancer cell lines, MCF-Ad5 and MCF-Ad10. Testicular carcinomas.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 36 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG' s
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF640R

Frequently Asked Questions

What is the catalog number for Thymidylate Synthase (TS106 + TMS715), CF640R conjugate, 0.1mg/mL?

The catalog number for Thymidylate Synthase (TS106 + TMS715), CF640R conjugate, 0.1mg/mL is BNC400716-500.

What sizes are available for Thymidylate Synthase (TS106 + TMS715), CF640R conjugate, 0.1mg/mL?

Thymidylate Synthase (TS106 + TMS715), CF640R conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is Thymidylate Synthase (TS106 + TMS715), CF640R conjugate, 0.1mg/mL in stock?

Thymidylate Synthase (TS106 + TMS715), CF640R conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Thymidylate Synthase (TS106 + TMS715), CF640R conjugate, 0.1mg/mL?

Thymidylate Synthase (TS106 + TMS715), CF640R conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Thymidylate Synthase (TS106 + TMS715), CF640R conjugate, 0.1mg/mL?

Estimated delivery time for Thymidylate Synthase (TS106 + TMS715), CF640R conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Thymidylate Synthase (TS106 + TMS715), CF640R conjugate, 0.1mg/mL?

The safety data sheet for Thymidylate Synthase (TS106 + TMS715), CF640R conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd0297061270361e1006f1/msds/bnc400716-500.pdf.

What is Thymidylate Synthase (TS106 + TMS715), CF640R conjugate, 0.1mg/mL used for?

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.

Can I get a trial-size or discounted first order of this product?

We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.