Thymidylate Synthase (TS106), CF647 conjugate, 0.1mg/mL

Catalog number BNC470714-500

Price for BNC470714-500

Size / count 1x 500 µL

About this product

This antibody recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45) . TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC470714-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: DTMP synthase, TMS, TS, TSase, TYMS protein, Tyms thymidylate synthetase
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: TYMS
Gene ID: 7298
NCBI Gene ID: 369762
UniProt: P04818
Swiss Prot: P04818
Host: Mouse
Species Reactivity: Human
Reactivity: Thymidylate Synthase
Immunogen: Recombinant human thymidylate synthase
Target Antigen: Thymidylate Synthase
Clonality: Monoclonal
Clone: TS106
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Field of Research: Cancer, Metabolism
Positive Control: 5-FU-resistant colon carcinoma cell lines (NCI H630R10, NCI H630R1); 5-FU-resistant breast cancer cell lines, MCF-Ad5 and MCF-Ad10. Testicular carcinomas.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 36 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF647

Frequently Asked Questions

What is the catalog number for Thymidylate Synthase (TS106), CF647 conjugate, 0.1mg/mL?

The catalog number for Thymidylate Synthase (TS106), CF647 conjugate, 0.1mg/mL is BNC470714-500.

What sizes are available for Thymidylate Synthase (TS106), CF647 conjugate, 0.1mg/mL?

Thymidylate Synthase (TS106), CF647 conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is Thymidylate Synthase (TS106), CF647 conjugate, 0.1mg/mL in stock?

Thymidylate Synthase (TS106), CF647 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Thymidylate Synthase (TS106), CF647 conjugate, 0.1mg/mL?

Thymidylate Synthase (TS106), CF647 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Thymidylate Synthase (TS106), CF647 conjugate, 0.1mg/mL?

Estimated delivery time for Thymidylate Synthase (TS106), CF647 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Thymidylate Synthase (TS106), CF647 conjugate, 0.1mg/mL?

The safety data sheet for Thymidylate Synthase (TS106), CF647 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd02a8061270361e10686b/msds/bnc470714-500.pdf.

What is Thymidylate Synthase (TS106), CF647 conjugate, 0.1mg/mL used for?

How do I reconstitute this lyophilized product?

Reconstitution instructions, including the recommended diluent and final concentration, are provided on the datasheet. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles.

What is the recommended incubation time for this antibody?

A suggested incubation time is provided in the recommended protocol on the datasheet, but may need adjusting depending on your sample type and detection system.

What should I check when this product first arrives?

Inspect the package immediately for transportation damage, ice loss, leakage, or breakage. Report any issues right away with photos and your order reference; our specialists will determine whether the product is still usable or needs replacing.