TYRP1 (Tyrosinase Related Protein 1) (TA99), CF405S conjugate, 0.1mg/mL

About this product

This antibody reacts with a 75 kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1) . It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNC040806-100

Size / count

1x 100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

5, 6 dihydroxyindole 2 carboxylic acid oxidase, 6-dihydroxyindole-2-carboxylic acid oxidase, Associated with iris pigmentation, CAS2, Catalase B (CATB), DHICA oxidase, Glycoprotein75 (GP75), Melanoma antigen gp75, Tyrosinase-related protein 1 (TYRP1), TYRRP

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

TYRP1

Gene ID

7306

NCBI Gene ID

270279

UniProt

P17643

Swiss Prot

P17643

Host

Mouse

Species Reactivity

Human, Mouse

Reactivity

TRP1

Immunogen

SK-MEL-23 cells

Target Antigen

TRP1

Clonality

Monoclonal

Clone

TA99

Type

Primary

Source

Animal

Origin

Animal

Applications

Flow, surface (published) |IF (published) |IHC, FFPE (published) |IHC, frozen (published) |IP (published)

Field of Research

Cancer

Positive Control

SK-MEL-23, SK-MEL-19, SK-MEL-30 cells or Melanoma.

Stability

2 years

Concentration

0.1 mg/mL

Buffer

PBS, 0.1% BSA, 0.05% azide

Molecular Weight

75 kDa

References & Citations

Note: References for this clone sold by other suppliers may be listed for expected applications. J Invest Dermatol (1985) 85:169-174. (IP; IHC, frozen) PNAS USA (1987) 84, 4200-4204. (in vivo imaging melanoma) J Exp Med (1995) 182: 1609-1614. (functional studies) J Cell Biol (2015) 209(4): 563-577. (Flow, surface; IF) J Cell Mol Med (2017) 21(4): 802-815. (IHC, FFPE)

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Notes

Protect from light

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG2a, kappa

Species

Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

Classification

0.05% sodium azide (CAS 26628-22-8)

Conjugate

CF405S