Tyrosinase (T311), CF405S conjugate, 0.1mg/mL — image 1 of 2

Product details

Tyrosinase (T311), CF405S conjugate, 0.1mg/mL

Catalog number BNC040012-500

Price for BNC040012-500

Size / count 1x 500 µL

About this product

Recognizes a cluster of proteins between 70-80 kDa, identified as tyrosinase. Occasionally a minor band at 55 kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC040012-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: ATN, CMM8, LB24-AB, Monophenol monooxygenase, OCA1, OCA1A, Oculocutaneous albinism IA, SHEP3, SK29-AB, Tumor rejection antigen AB, TYR
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: TYR
Gene ID: 7299
NCBI Gene ID: 503555
UniProt: P14679
Swiss Prot: P14679
Host: Mouse
Species Reactivity: Human
Reactivity: Tyrosinase
Immunogen: Recombinant tyrosinase protein
Target Antigen: Tyrosinase
Clonality: Monoclonal
Clone: T311
Type: Primary
Source: Animal
Origin: Animal
Applications: Flow, intracellular (published) |ELISA (published) |IHC, FFPE (verified) |IP (published) |WB (published)
Field of Research: Cancer
Positive Control: SK-MEL-19, SK-MEL-30 cells or Melanoma.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 70-80 kDa
References & Citations: Note: References for this clone sold by other suppliers may be listed for expected applications. J Clin Pathol (2001) 54:196-200. (IHC, FFPE) PNAS USA (1995) 92: 8125-8129. (WB, IHC, ELISA) J Biol Chem (2001) 276(15): 11933-11938. (WB, IP) Cytometry Part A (2012) 81A: 374381. (Flow, intracellular)
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG2a, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF405S

Frequently Asked Questions

What is the catalog number for Tyrosinase (T311), CF405S conjugate, 0.1mg/mL?

The catalog number for Tyrosinase (T311), CF405S conjugate, 0.1mg/mL is BNC040012-500.

What sizes are available for Tyrosinase (T311), CF405S conjugate, 0.1mg/mL?

Tyrosinase (T311), CF405S conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is Tyrosinase (T311), CF405S conjugate, 0.1mg/mL in stock?

Tyrosinase (T311), CF405S conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Tyrosinase (T311), CF405S conjugate, 0.1mg/mL?

Tyrosinase (T311), CF405S conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Tyrosinase (T311), CF405S conjugate, 0.1mg/mL?

Estimated delivery time for Tyrosinase (T311), CF405S conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Tyrosinase (T311), CF405S conjugate, 0.1mg/mL?

The safety data sheet for Tyrosinase (T311), CF405S conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is Tyrosinase (T311), CF405S conjugate, 0.1mg/mL used for?

What is the purity of this recombinant protein?

Purity, typically assessed by SDS-PAGE, is listed on the datasheet under quality control data.

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.