VEGFR2 / Flk-1 / KDR3 / CD309 (KDR721), CF647 conjugate, 0.1mg/mL

About this product

CD309, also known as VEGFR2, KDR3, and Flk-1 (mouse), is a type I transmembrane glycoprotein. It is a member of the CSF-1/PDGF receptor family of type III tyrosine kinase receptors. Human VEGFR2 is mainly expressed by endothelial cells, embryonic tissues, and megakaryocytes. It plays an important role in the regulation of angiogenesis, vasculogenesis, and vascular permeability. The ligands of VEGFR2 include VEGF-A, VEGF-C, VEGF-D, and VEGF splice isoforms. Ligation of VEGFR2 with its ligands results in the receptor dimerization and auto-phosphorylation, stimulating endothelial cell proliferation and migration.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNC470721-500

Size / count

1x 500 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

CD309; Fetal liver kinase 1 (FLK-1) ; KDR; Kinase insert domain receptor (a type III receptor tyrosine kinase) ; KRD1; Ly73; Protein tyrosine kinase receptor FLK1; Protein-tyrosine kinase receptor flk-1; Vascular endothelial growth factor receptor 2

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

KDR

Gene ID

3791

NCBI Gene ID

479756

UniProt

P35968

Swiss Prot

P35968

Host

Mouse

Species Reactivity

Human

Reactivity

CD309|Flk-1|KDR3|VEGFR2

Immunogen

Recombinant human VEGF-R2 protein

Target Antigen

CD309 | Flk-1 | KDR3 | VEGFR2

Clonality

Monoclonal

Clone

KDR721

Type

Primary

Source

Animal

Origin

Animal

Field of Research

Angiogenesis, Cancer

Positive Control

HUVEC cells. Human lymph nodes and tonsils.

Stability

2 years

Concentration

0.1 mg/mL

Buffer

PBS, 0.1% BSA, 0.05% azide

Molecular Weight

150-230 kDa

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Notes

Protect from light

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG1, kappa

Species

Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

Classification

0.05% sodium azide (CAS 26628-22-8)

Conjugate

CF647